Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Kingstn 3rd year Section 2 > Gastro Intestinal > Flashcards

Gastro Intestinal Flashcards

1
Q

What type of viruses are the main cause of diarhoea

A

Enteric viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What age group do enteric viruses affect the most and why?

A

children

less common in adults due to acquired immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How many days incubation typically is GI disease?

What does it lead to (2 symptoms)

A

1-2 days

Diarrhoea

Projectile Vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which type of virus is the most common cause of GI

A

Rotavirus (type A =90%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What part of the intestine does the rota virus affect? What does it lead to for the stools?

A

upper small intestine = watery stools

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

whats the symptoms for the first part of rotavirus GI?

A

initially symptomless

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what route is the Rotavirus transmitted by?

A

Faecal oral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rotavirus is part of what family

A

Reoviridae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the structure of rotavirus?

A

70nm

Wheel shape

Linear dsRNA (18kb in 11 segments)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What diagnosis is done for Rotavirus what antigen? Whats difficult to do for traditional diagnosis

A

ELISA for stool sample VP6

Cell culture difficult to do

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What group adeno virus affects GI?

What group adeno affects respiratory system

A

F

B/C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What diagnosis is done for adeno virus ANTIGENS

A

ELISA for Hexon antigens

Clinician + symptoms presenting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

structure of adeno virus

A

80-110nm / Icosahedral / linear dsDNA 36kb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What age group does the astrovirus mainly affect?

where do outbreaks mainly occur for astroviruses

A

Children

Hospitals / families

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

whats the astrovirus similar to? what does it differ by?

A

SRSV

different virions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How many serotypes of astroviruses are present?

can it be grown on TC

A

5 serotypes

difficult to grow on TC

17
Q

Structure of Astrovirus

What antigen is detected in ELISA?

A

30nm / 5-6 pointed star / positive ssRNA 7kb

VP26

18
Q

Name a SRSV

What is it a part of?

A

norovirus

Part of calicivirus family

19
Q

What two conditions arise from Norovirus?

What is the incubation time for Norvirus

A

Winter vomiting disease / Diarrhoea

24-48 hr incubation

20
Q

What are 3 general symptoms from norovirus

A

Ab cramp // vomiting // low grade fever

21
Q

no ….. generally with norovirus

A

sequelae

22
Q

Route of transmission of norovirus (2)

A

Faecal oral route

Environment w/vomitus

23
Q

Outbreaks of norovirus are associated with?

A

shellfish + water

24
Q

Structure of norovirus

A

linear ssRNA 7kb // cup like indents // 23-40nm

25
Q

How is norovirus diagnosed

A

Doesnt grow on culture

PCR / EM used

26
Q

Whats happening to the number of cases for norovirus

where is there a hotspot for norovirus

A

increasing number of cases

common on cruise ships

27
Q

Astroviruses number of cases are?

What type of climate is associated with an increase in infections during winter?

A

decreasing

temperate climate

28
Q

Whats happening to the number of cases of rota viruses cases?

A

consistent but seasonal variation in winter

Endemic Worldwide

29
Q

Testing for MAB / development of vaccines has improved for norovirus why? (medical economics 2018)

A

organic intestinal cultures created

norovirus struggles to grow on TC so needs organic environment

30
Q

What does the rotavirus produce that makes it pathogenic?

A

Enterotoxin

31
Q

What does the Astrovirus do that makes it pathogenic?

A

Destroys the intestinal epithelium

32
Q

What are the two problems that arrise with vaccines for rotavirus

A

reassortment

Intussusception

33
Q

Why is reinfection more common in norovirus

A

short incubation time + short time being pathogenic means it causes a brief immunity

34
Q

What sort of vaccine is given for rota virus

What does this give?

A

Oral live attenuated vaccine

Gut immunity

Kingstn 3rd year Section 2 (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions