Hepatitis Flashcards
Where do hepatitis viruses replicate?
in hepatocytes
five liver function tests?
Bilirubin Liver transaminases Alkaine phosphatase Albumin Coagulation tests
How is Hep B transmitted?
Vertical
Sexual
IV drug users (Blood)
5 symptoms of Hep B
Jaundice Fatigue Abdo pain Anorexia, nause, vomiting Arthralgia
Incubation period of Hep B?
6wks-6months
Describe the serology of Hep B
Surface antigen first
Then E antigen, and in this stage, highly infectious
The core antibody (IgM
Followed by e antibody (Disappearance of e antigen and infectivity)
Then surface antibody (Last antibody to appear. Indicates clearance of virus and so recovery)
Core antibody (IgG) persists for life
Define chronic Hep B infection
Persistence of Hep B surface antigen after 6 months
Complications of chronic Hep B
cirrhosis
Hepatocellular carcinoma
Describe what serological tests would be positive in the following situations: Acute infection Cleared infection CHronic infection Never infected, but has been vaccinated
Surface antgen, core antibody, surface antibody
Acute infection:Surface antigen, core antibody (IgM), may or may not have surface antibody
Cleared infection: Core antibody (IgG), Surface antibody
Chronic Infection: Surface antigen, Core anntibody (IgG)
Vaccinated: Surface antibody
What antigen is used in vaccination?
Surface antigen
How is Hep C transmitted?
IV drugs
Sexual
Vertical transmission
Approx what percentage become chronically infected with Hep C
80%
Complications of chronic Hep C infections?
Cirrhosis
Decompensated liver disease
hepatocellular carcinoma
Symptoms of Hep C?
80% have no symptoms
20%, symptoms are vague
Serology of Hep C?
anti-Hep C antibody only
If positive, could have had in the past
