Hepatitis

Question 1

Signs and symptoms of hepatitis

Answer 1

Many asymptomatic. Malaise, nausea, body aches, headaches, loss of appetite, low grade fever, abdominal pain

Question 2

Etiology of Hepatitis

Answer 2

Infection, immune related: autoimmune/PBC/PSC. Chemical/toxin, meds, ischemia. Hereditary: Wilson’s, hemochromatosis, alpha 1 anti trypsin. Pregnancy, alcohol, non alcoholic fatty liver disease

Question 3

auto immune hepatitis

Answer 3

more common in females. ALT/AST increased, ANA positive, anti smooth muscle antibody and anti LKM antibodies positive. Portal triaditis. treated with steroids or immunemodulators ie: Azathioprine

Question 4

Primary Biliary Cirrhosis

Answer 4

Immune system selectively attacks bile ducts. >80% of pts have an anti mitochondrial antiody. Elevated cholesterol common. High risk of osteoporosis. Treat with Urso (bile acid supplement)

Question 5

Primary sclerosing cholangitis

Answer 5

Immune mediated stricturing of the biliary tree. Involves intra and extra hepatic duct systems. Associated with ulcerative colitis and crohn’s disease. May be ANCA+. No medical therapy available, even with transplant

Question 6

Causes of toxin induced hepatitis

Answer 6

Tylenol, amanita phalloides, white phosphorus, carbon tetrachloride

Question 7

What hepatitis is only DNA virus

Answer 7

Hep B

Question 8

How long does pt with acute Hep B until treatment

Answer 8

6 months

Question 9

Only treatment to wipe out Hep B

Answer 9

Interferon

Question 10

Only hep drug safe for use in pregnant women?

Answer 10

Lamivudine

Question 11

What country has highest rate of Hep C

Answer 11

Egypt

Question 12

Name 2 direct anti viral agents

Answer 12

Telaprevir and Voceprevir. Both are protease inhibitors. Rapid viral resistance with monotherapy