Hepatic & Immunity Flashcards

1
Q

This kind of immunity responds to foreign invaders without prior exposure. It can be characterized as a quick response and a first line of defense.

A

Natural/innate

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2
Q

This kind of immunity refers to the immunologic defenses developed by the person’s own body (i.e. from prior illness).

A

Active acquired immunity

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3
Q

This kind of immunity is a temporary immunity transmitted from a source outside the body that has developed immunity from previous disease or immunization (e.g. through breast milk).

A

Passive acquired immunity

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4
Q

These are symptoms of what infection?

A

HIV

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5
Q

Systemic symptoms of this infection

A

TB

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6
Q

How does liver impairment affect the following functions of the liver (increase or decrease)?

Glucose metabolism
Ammonia conversion
Protein metabolism
Fat metabolism
Vitamin and Iron Storage
Bile formation
Bilirubin excretion
Drug metabolism
Clotting factors

A

-Glucose:(hypo OR hypergycemia
-Ammonia conversion ↑
-Protein metabolism ↓
Fat metabolism & absorption ↓
Vitamin and Iron Storage ↓
Bile formation ↓
Bilirubin ↑
Drug metabolism ↓
Clotting factors ↓ – so time to clot ↑

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7
Q

What stage of Hepatic Encephalopathy is this:

Normal level of consciousness with periods of lethargy and euphoria; reversal of day-night sleep patterns. Impaired writing and ability to draw line figures. Normal EEG.

A

Stage 1

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8
Q

What stage of Hepatic Encephalopathy is this:

Stuporous; sleeps most of the time; marked confusion; incoherent speech; asterixis; increased deep tendon reflexes, rigidity of extremities. EEG markedly abnormal.

A

Stage 3

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9
Q

What stage of Hepatic Encephalopathy is this:

Increased drowsiness; disorientation; inappropriate behavior; mood swings; agitation; asterixis; fetor hepaticus. Abnormal EEG with generalized slowing.

A

Stage 2

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10
Q

Neurological condition that causes involuntary flapping of the wrists and fingers. Also known as flapping tremor.

A

Asterixis

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11
Q

A condition where the breath has a musty smell, sometimes like garlic or rotten eggs

A

Fetor hepaticus

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12
Q

What stage of Hepatic Encephalopathy is this:

Comatose; may not respond to painful stimuli; absence of asterixis; absence of deep tendon reflexes; flaccidity of extremities. EEG markedly abnormal.

A

Stage 4

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13
Q

Permanent scarring of the liver that is caused by chronic inflammation or necrotic injury. Normal liver tissue is replaced with fibrotic tissue that lacks function.

A

Cirrhosis

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14
Q

In these types of viral hepatitis, the route of transmission is fecal-oral. It can be contracted after ingestion of contaminated food or water, or during anal sex.

A

Hepatitis A
Hepatitis E

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15
Q

These types of viral hepatitis are contracted from dirty needs or sex.

A

Hepatitis B, C

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16
Q

Signs and Symptoms of hepatitis

A

Flu-like: Fever, Fatigue, decreased appetite, nausea/vomiting, abdominal pain, joint pain

Dark-colored urine, clay colored stool, jaundice

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17
Q

The liver enzyme may be elevated or normal in hepatitis

A

ALP

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18
Q

This type of hepatitis is contracted as a co-infection with Hep B

A

Hepatitis D

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19
Q

Patient position for a liver biopsy

A

Supine during the procedure. After, right side-lying position for several hours. This position compresses the liver capsule against the chest wall, therefore, decreasing the risk of bleeding.

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20
Q

True or false: following a liver biopsy, the nurse applies pressure to the puncture site.

A

True

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21
Q

Following a liver biopsy, dyspnea, cyanosis, and/or restlessness may indicate what potential complication?

A

Pneumothorax due to accidental puncture of the pleura or lung

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22
Q

True or False: following a liver biopsy, the nurse should instruct the patient to do deep breathing and coughing.

A

False: the patient should avoid coughing and straining to prevent increased intraabdominal pressure and bleeding

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23
Q

Combination therapy with peginterferon alfa-2a and ribavirin is the preferred treatment for this type of viral hepatitis

A

Hepatitis C

24
Q

No medications are recommended for acute infection with these types of viral hepatitis (supportive care only)

A

Hepatitis B and Hepatitis E

25
Chronic infection with this type of viral hepatitis is treated with antiviral medications (tenofovir, adefovir, dipivoxil, interferon alfa-2b, peginterferon alfa-2a, lamivudine, entecavir, telbivudine)
Hepatitis B
26
Are antiviral medications used for acute or chronic infection with Hepatitis B?
Chronic
27
These types of viral hepatitis can result in chronic infection
Hepatitis B, C, or D
28
For post-exposure prophylaxis (PEP) of hep A, this therapy is recommended for clients over 40, younger than 1 year, or those who have chronic liver disease, who are immunocompromised or allergic to the vaccine. (For all other patients, the vaccine would be given instead as PEP.
Immunoglobulin
29
This type of immunity involves supplying pre-formed antibodies.
Passive Immunity
30
How does liver failure affect the following levels: ALT & AST (often >1000 U/L) Bilirubin PT/INR (coagulopathy) Albumin Ammonia
↑ ALT & AST (often >1000 U/L) ↑ Bilirubin ↑ PT/INR (coagulopathy) ↓ Albumin Ammonia would be elevated in encephalopathy
31
When levels are too high, this neurotoxin crosses the blood-brain barrier and causes confusion, asterixis, and even coma.
Ammonia
32
A life-threatening condition that causes acute liver failure in days or hours - usually in a person with no preexisting liver disease. Most often caused by viral hepatitis or drugs such as a Tylenol overdose
Fulminant hepatitis
33
A life-threatening complication of liver failure. Toxic substances, which are normally detoxified by the liver, enter systemic circulation. Ammonia levels rise and enter the brain, causing clients to develop changes in neurologic status that can progress to stupor, asterixis (hand flapping), fetor hepaticus (fruity, musty breath odor), seizures, and coma.
Hepatic encephalopathy
34
This type of cirrhosis is caused by viral hepatitis, certain medications or toxins.
Postnecrotic
35
This type of cirrhosis is caused by chronic alcohol use disorder
Laennec's
36
This type of cirrhosis is caused by chronic biliary obstruction or autoimmune disease
Biliary
37
The only definitive cure for end-stage cirrhosis
Liver transplant
38
What kind of heart failure causes cardiac cirrhosis - induces necrosis and fibrosis due to lack of blood flow
Severe right heart failure
39
melena
black stools
40
Elevated blood pressure in veins that carry blood from the intestines to the liver
Portal hypertension
41
Because portal hypertension restricts normal blood flow, the body compensates by creating these secondary pathways, often in the esophagus and upper stomach. However, these newly formed veins are fragile and prone to rupture, which can lead to life-threatening bleeding
Esophageal varices
42
What are the early warning signs that a patient may experience bleeding from esophageal varices?
Gastrointestinal discomfort, fullness, or pressure Mild nausea before an episode of bleeding Dropping HgB and HcT also indicate blood loss.
43
When might a patient with cirrhosis require any of the following interventions: Saline lavage (vasoconstriction), esophagogastric balloon tamponade, blood transfusions, ligation and sclerotherapy, and shunts
These interventions are all indicated for esophageal varices - they stop bleeding and reduce the risk of hypovolemic shock
44
How many days after surgery does rejection typically occur following a liver transplant?
4-10 days after surgery
45
What are the signs of a liver transplant is being rejected by the host?
Tachycardia Upper right flank pain Jaundice Laboratory findings of liver failure
46
Basophils: elevation means what?
Allergic reactions, rare caues
47
Neutrophils: elevation means what?
bacterial infection
48
Leukocytes: elevation means what?
Viral infection
49
Monocytes: elevation means what?
Chronic infection (TB), autoimmune disease
50
Eosinophils: elevation means what?
Allergies, parasites
51
What to watch for with a platelet count <150,000/mm³
Mild risk for bruising, bleeding gums
52
What to watch for with a platelet count <50,000/mm³
Serious risk – bleeding with trauma
53
What to watch for with a platelet count <20,000/mm³
Spontaneous bleeding (nose, GI, etc.)
54
What to watch for with a platelet count <10,000/mm³
Emergency – risk for brain bleeds
55
Client education for low platelet count or high PT/INR
Use soft toothbrush, electric razor, and avoid NSAIDs. Report any bruising, nosebleeds, or black/tarry stools
56
Elevated Mean Corpuscular Volume aka macrocytosis ( ↑ MCV = large RBCs) is often caused by: medication effects like (antiretrovirals or chemo), alcohol use, liver disease or a deficiency or this vitamine
Vitamin B12 or folate
57