Hepatic Drugs Flashcards by E D

Octreotide: class

Somatastatin analogue

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Octreotide: MOA

Inhibits bowel secretion
Dose related impact on motility,
Splanchnic arteriole constriction

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Octreotide: indication

Diarrhea secondary to bowel dysmotility, carcinoid, VIP-oma, vagotomy, dumping syndrome, short bowel syndrome, HIV diarrhea, GI bleed

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Octreotide: side effects

Steatorrhea, Gallstones (>50% with long term use)

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Octreotide: contraindication

Bowel obstruction

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Octreotide: Dx-Dx

Insulin, PO hypoglycemics, BBs, CCBs

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Interferon alpha (INFa): class

Interferon

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INFa: MOA

Multiple anti-viral, immune modulating, anti-viral proliferation effects

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INFa: indication

HBV, HCV

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INFa: side effects

Flu like sxs initially, may unmasked auto immune disease

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INFa: contraindication

Autoimmune disease, phych d/o, epilepsy, thyroid d/o, pregnancy (abortifactant)

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What increases the t1/2 of INFa?

polyethylene glycol (PEG)

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Ofloxacin: class

FQ abx

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Ofloxacin: MOA

Inhibits bacterial DNA replication by binding to DNA gyrase and topoisomerase

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Ofloxacin: indication

Susceptible GI/GU infection

Traveler’s diarrhea (off label)

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A major side effect of all FQs

Tendonitis/rupture

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Epivir: class

Anti-viral

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Epivir: MOA

Inhibits HBV DNA polymerase and HIV reverse transcriptase

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Epivir: indications

HBV, HIV

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Epivir: side efect

Resistance may develop

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Is Epivir safe to take during pregnancy?

Yes

Ribavarin: class

Anti-viral

Ribavarin: MOA

Inhibits replication of a wide variety of DNA and RNA viruses

Ribavarin: indications

HCV, HIV

What is Ribavarin's big goal?

HCV eradication

Ribavarin: side effect

*Teratogenic

Ribavarin: contraindication

Preganancy, being the partner of a pregnant woman (for 6 mo after Tx)

What is usually used in combo with Ribavarin?

INFa

Sovaldi: class

Direct acting anti-viral

Sovaldi: MOA

Inhibits HCV RNA polymerase, preventing replication

Sovaldi: indication

Acute or chronic HCV

Sovaldi: side effects

Flu-like sxs, insomnia, pruritis

Sovaldi: contraindication

Pregnancy

Sovaldi: Dx-Dx

P-gp inducers/inhibitors

Harvoni: class

Combo direct acting anti-viral

Harvoni: MOA

L: inhibits HCV protein necessary for replication S: inhibits HCV RNA polymerase

Harvoni: indication

Chronic HCV-1

Oddly, what is Harvonis PG class?

Rifaximin: class

Misc. abx

Rifaximin: MOA

Inhibits bacterial RNA synthesis by binding to polymerase

Rifaximin: indications

Hepatic encephalopathy *IBS diarrhea Traveler's diarrhea C. diff diarrhea (off label)

Rifaximin: side effect

Pseudomembranous colitis

Rifaximin: metabolic pathway

CYP3A4 in bowel lumen

How much Rifaximin is excreted unchanged?

97%

Havrix: class

HAV vaccine

Havrix: MOA

Stimulated HAV Ab production

Havrix: indication

Active HAV Px (pre or post exposure); 2 doses

Havrix: contraindication

Neomycin allergy

Engerix-B: class

HBV vaccine

Engerix-B: MOA

Stimulates HBV Ab production

Engerix-B: indication

Active HBV Px; 3 doses

Engerix-B: contraindiaction

Yeast allergy