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GI Pharm > Hepatic Drugs > Flashcards

Hepatic Drugs Flashcards

1
Q

Octreotide: class

A

Somatastatin analogue

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2
Q

Octreotide: MOA

A

Inhibits bowel secretion
Dose related impact on motility,
Splanchnic arteriole constriction

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3
Q

Octreotide: indication

A

Diarrhea secondary to bowel dysmotility, carcinoid, VIP-oma, vagotomy, dumping syndrome, short bowel syndrome, HIV diarrhea, GI bleed

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4
Q

Octreotide: side effects

A

Steatorrhea, Gallstones (>50% with long term use)

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5
Q

Octreotide: contraindication

A

Bowel obstruction

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6
Q

Octreotide: Dx-Dx

A

Insulin, PO hypoglycemics, BBs, CCBs

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7
Q

Interferon alpha (INFa): class

A

Interferon

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8
Q

INFa: MOA

A

Multiple anti-viral, immune modulating, anti-viral proliferation effects

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9
Q

INFa: indication

A

HBV, HCV

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10
Q

INFa: side effects

A

Flu like sxs initially, may unmasked auto immune disease

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11
Q

INFa: contraindication

A

Autoimmune disease, phych d/o, epilepsy, thyroid d/o, pregnancy (abortifactant)

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12
Q

What increases the t1/2 of INFa?

A

polyethylene glycol (PEG)

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13
Q

Ofloxacin: class

A

FQ abx

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14
Q

Ofloxacin: MOA

A

Inhibits bacterial DNA replication by binding to DNA gyrase and topoisomerase

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15
Q

Ofloxacin: indication

A

Susceptible GI/GU infection

Traveler’s diarrhea (off label)

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16
Q

A major side effect of all FQs

A

Tendonitis/rupture

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17
Q

Epivir: class

A

Anti-viral

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18
Q

Epivir: MOA

A

Inhibits HBV DNA polymerase and HIV reverse transcriptase

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19
Q

Epivir: indications

A

HBV, HIV

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20
Q

Epivir: side efect

A

Resistance may develop

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21
Q

Is Epivir safe to take during pregnancy?

A

Yes

22
Q

Ribavarin: class

A

Anti-viral

23
Q

Ribavarin: MOA

A

Inhibits replication of a wide variety of DNA and RNA viruses

24
Q

Ribavarin: indications

A

HCV, HIV

25
Q

What is Ribavarin’s big goal?

A

HCV eradication

26
Q

Ribavarin: side effect

A

*Teratogenic

27
Q

Ribavarin: contraindication

A

Preganancy, being the partner of a pregnant woman (for 6 mo after Tx)

28
Q

What is usually used in combo with Ribavarin?

A

INFa

29
Q

Sovaldi: class

A

Direct acting anti-viral

30
Q

Sovaldi: MOA

A

Inhibits HCV RNA polymerase, preventing replication

31
Q

Sovaldi: indication

A

Acute or chronic HCV

32
Q

Sovaldi: side effects

A

Flu-like sxs, insomnia, pruritis

33
Q

Sovaldi: contraindication

A

Pregnancy

34
Q

Sovaldi: Dx-Dx

A

P-gp inducers/inhibitors

35
Q

Harvoni: class

A

Combo direct acting anti-viral

36
Q

Harvoni: MOA

A

L: inhibits HCV protein necessary for replication
S: inhibits HCV RNA polymerase

37
Q

Harvoni: indication

A

Chronic HCV-1

38
Q

Oddly, what is Harvonis PG class?

A

B

39
Q

Rifaximin: class

A

Misc. abx

40
Q

Rifaximin: MOA

A

Inhibits bacterial RNA synthesis by binding to polymerase

41
Q

Rifaximin: indications

A

Hepatic encephalopathy
*IBS diarrhea
Traveler’s diarrhea
C. diff diarrhea (off label)

42
Q

Rifaximin: side effect

A

Pseudomembranous colitis

43
Q

Rifaximin: metabolic pathway

A

CYP3A4 in bowel lumen

44
Q

How much Rifaximin is excreted unchanged?

A

97%

45
Q

Havrix: class

A

HAV vaccine

46
Q

Havrix: MOA

A

Stimulated HAV Ab production

47
Q

Havrix: indication

A

Active HAV Px (pre or post exposure); 2 doses

48
Q

Havrix: contraindication

A

Neomycin allergy

49
Q

Engerix-B: class

A

HBV vaccine

50
Q

Engerix-B: MOA

A

Stimulates HBV Ab production

51
Q

Engerix-B: indication

A

Active HBV Px; 3 doses

52
Q

Engerix-B: contraindiaction

A

Yeast allergy

GI Pharm (5 decks)

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