Anti-emetic Drugs

Question 1

Transderm Scop: class

Answer 1

Anticholinergic

Question 2

Transderm Scop: MOA

Answer 2

Blocks Ach activity at PNS sites in smooth muscle, secretory glands, and CNS

Question 3

Transderm Scop: indications

Answer 3

Nausea, vertigo

Question 4

Transderm Scop: side effects

Answer 4

Dry mouth, CNS depression

Question 5

Transderm Scop: contraindications

Answer 5

Paraltyic Ileus, myasthenia gravis, narrow angle glaucoma

Question 6

When should you apply Transderm Scop?

Answer 6

Well before you need it!

Question 7

Phenergan: class

Answer 7

Phenothiazine

Question 8

Phenergan: MOA

Answer 8

Blocks CNS D2 receptors and competes for H1 receptors

Question 9

Phenergan: indication

Answer 9

Anti-emetic
Motion sickness
Sedation

Question 10

Phenergan: side effects

Answer 10

Extrapyramidal sxs

Very sedating

Question 11

Phenergan: contraindications

Answer 11

Parkingson’s

seizure d/o

Question 12

Haloperidol: class

Answer 12

Butyrophenone

Question 13

Haloperidol: MOA

Answer 13

Blocks post synaptic mesolimbic D1/D2 receptors;

**Suppresses RAS

Question 14

Haloperidol: indication

Answer 14

Anti-emetic

*but no one uses it for this in practice

Question 15

Haloperidol: side effects

Answer 15

Agitation, akithesia, altered temp regulation, tardive dyskinesia

Question 16

Reglan: class

Answer 16

Benzamide

Question 17

Reglan: MOA

Answer 17

Blocks D and 5-HT receptors in CRTZ

Question 18

Reglan: indication

Answer 18

Anti-emetic,

Diabetic gastroparesis

Question 19

Reglan: side effects

Answer 19

Pseudo parkinsonism, tardive dyskinesia

Question 20

Reglan: contraindication

Answer 20

Bowel obstruction

Question 21

Dexamethasone: class

Answer 21

Corticosteroid

Question 22

Dexamethasone: MOA

Answer 22

Enhances effect of 5-HT3 receptor antagonists in CRTZ

Question 23

Dexamethasone: indication

Answer 23

Anti-emetic

Question 24

Dexamethasone: side effects

Answer 24

With one dose - none really

Question 25

When do you have to administer Dexamthasone in order for it to work?

Answer 25

Before you need it.

Question 26

Marinol: class

Answer 26

Cannaboid

Question 27

Marinol: MOA

Answer 27

Unknown

Question 28

Marinol: indication

Answer 28

appetite stimulant,

Chemo-related antiemetic

Question 29

What drug do you combine with Marinol to have a synergistic effect?

Answer 29

Phenergan

Question 30

Zofran: class

Answer 30

Serotonin antagonist

Question 31

Zofran: MOA

Answer 31

Peripheral and CRTZ 5-HT3 receptor blockade

Question 32

Zofran: indication

Answer 32

post-op, radiation, and chemo-induced N/V

Question 33

Zofran: side effect

Answer 33

Long QT

Question 34

Which is more effective: scheduled Zofran or PRN?

Answer 34

Scheduled

Question 35

Emend: class

Answer 35

NK-1 antagonist

Question 36

Emend: MOA

Answer 36

Blocks central NK-1 receptors;

Augments anti-emetic effects of 5-HT3 receptor antagonists and corticosteroids

Question 37

Emend: indication

Answer 37

Prevention of chemo induced and post-op N/V

Question 38

Naloxegol: class

Answer 38

Peripheral acting opioid antagonist

Question 39

Naloxegol: MOA

Answer 39

Mu opioid receptor antagonist coupled with PEG (helps not cross the BBB)

Question 40

Naloxegol: indication

Answer 40

Opioid-induced constipation

Question 41

Naloxegol: side effect

Answer 41

Hyperhydrosis

Question 42

Naloxegol: Dx-Dx

Answer 42

CYP3A4 substrates

Question 43

To what dose do you reduce Naloxegol when the GFR falls below 60?

Answer 43

12.5mg/day