Hepatic

Question 1

Cholangiohepatitis in cattle has been defined as what?

Answer 1

Presence of portal inflammation surrounding or infiltrating bile ducts, with or without epithelial damage and extending into adjacent lobules.

10.1111/jvim.14675

Question 2

What are some biochem parameters that can be elevated in cattle with cholangiohepatitis? How else could these changes be interpreted?

Answer 2

GGT - a cholestatic enzyme; can be high in neonates due to colostrum

AST - liver leakage enzyme, but also found in muscle, erythrocytes and cardiac muscle

ALP - cholestatic enzyme and is more reliable as chronic liver dz marker in equids; also comes from bone and intestines

SDH - liver specific and useful for active hepatocellular necrosis; chronicity may show normal SDH levels

10.1111/jvim.14675