Hemostasis

Question 1

Which of the following statements is CORRECT?

A. Factor X catalyzes the conversion of prothrombin to thrombin.
B. Thrombin catalyzes the conversion of fibrinogen to fibrin.
C. Factor XIII catalyzes the cross-linking of fibrin.
D. Plasminogen catalyzes the hydrolysis of fibrin.

Answer 1

B

Question 2

Which of the following statements is/are INCORRECT?

A. Factor X catalyzes the conversion of prothrombin to
thrombin.
B. Thrombin catalyzes the conversion of fibrinogen to fibrin.
C. Plasmin catalyzes the hydrolysis of fibrin.
D. Both A and B

Answer 2

A

Question 3

Which of the following statements is/are INCORRECT?

A. The intrinsic pathway is activated by tissue thromboplastin.
B. Tissue thromboplastin is released in response to trauma.
C. The extrinsic pathway is activated by collagen.
D. Both A and C

Answer 3

D

Question 4

Which of the following statements is/are INCORRECT?

A. Factors II, VII, IX and X are all vitamin K-independent coagulation factors.
B. Functional vitamin K-dependent coagulation factors all contain gamma-carboxyglutamate, which facilitates binding of calcium ions.
C. Vitamin K immediately reverses the toxicity produced by warfarin.
D. Both B and C

Answer 4

C

Question 5

Which of the following statements is/are INCORRECT?

A. A thrombus is formed in the intravascular space during life.
B. Vitamin K deficiency predisposes to thrombus formation.
C. Antithrombin deficiency predisposes to thrombus formation.
D. Both A and B.

Answer 5

B

Question 6

Which of the following statements is/are INCORRECT?

A. Warfarin is used clinically as a thrombolytic agent.
B. Heparin interferes with the final common pathway
of coagulation.
C. Cross-linking of fibrin renders thrombi more susceptible to thrombolysis.
D. Both A and C

Answer 6

D

Question 7

Which of the following statements is INCORRECT?

A. Factor Xa catalyzes the conversion of prothrombin to thrombin.
B. Thrombin catalyzes the conversion of fibrinogen to fibrin.
C. Factor XIIIa catalyzes the cross-linking of fibrin.
D. Plasminogen catalyzes the hydrolysis of fibrin.

Answer 7

D

Question 8

Which of the following statements is INCORRECT?

A. The intrinsic pathway is activated by contact with collagen.
B. The extrinsic pathway is activated by tissue thromboplastin.
C. Both the intrinsic and extrinsic pathways generate Factor VIIa.
D. Tissue thromboplastin is released in response to trauma.

Answer 8

C

Question 9

Which of the following statements is INCORRECT?

A. Factors II, VII, IX and X are vitamin K-independent coagulation factors.
B. Vitamin K is required for proper posttranslational modification of vitamin K-dependent coagulation factors.
C. Functional vitamin K-dependent coagulation factors all contain gamma-carboxyglutamate.
D. Gamma-carboxyglutamate is required for proper binding of calcium ions by vitamin K-dependent coagulation factors.

Answer 9

A

Question 10

Which of the following statements is INCORRECT?

A. By definition, a thrombus is formed within the intravascular space.
B. By definition, a thrombus is formed prior to death.
C. By definition, a thromboembolus is derived from a thrombus.
D. By definition, a thromboembolus is derived from an embolus.

Answer 10

D

Question 11

Which of the following statements is INCORRECT?

A. Smoking predisposes to thrombus formation.
B. Hypertension predisposes to thrombus formation.
C. Antithrombin deficiency predisposes to thrombus formation.
D. Vitamin K deficiency predisposes to thrombus formation.

Answer 11

D

Question 12

Which of the following statements is INCORRECT?

A. Fibrinolysis normally occurs in the course of healing traumatized tissue.
B. Fibrinolysis entails conversion of fibrin into soluble proteolytic fragments.
C. Tissue plasminogen activator is clinically useful as a thrombolytic agent.
D. Cross-linking of fibrin renders thrombi more susceptible to thrombolysis.

Answer 12

D

Question 13

Which of the following statements is INCORRECT?

A. Heparin is a lipoprotein released by traumatized tissues.
B. Heparin binds both thrombin and antithrombin.
C. Heparin interferes with the final common pathway of coagulation.
D. Heparin is clinically useful for rapid-onset anticoagulation therapy.

Answer 13

A

Question 14

Which of the following statements is INCORRECT?

A. Warfarin is a vitamin K antagonist.
B. Warfarin is clinically useful for long-term anticoagulation therapy.
C. Vitamin K rapidly reverses the toxicity produced by warfarin.
D. Fresh-frozen plasma counteracts anticoagulation due to warfarin.

Answer 14

C

Question 15

Which of the following is incorrect?

a. by definition, thrombus is formed within intravascular
space
b. by definition, thrombus is formed prior to death
c. thromboembolus is derived from thrombus
d. thromboembolus is formed under normal circumstances

Answer 15

d

Question 16

Which of the following statements is incorrect?

a. Factors I, II, VII, IX are vitamin K dependent coagulation factors
b. Vitamin K is required for the post-translational modification of vitamin K-dependent coagulation factors
c. Functional vitamin K-dependent coagulation factors all contain gammacarboxyglutamate
d. Gamma carboxyglutamate is required for the proper binding of calcium factors.

Answer 16

a

Question 17

Which of the following is incorrect?

a. Prothrombin is converted to thrombin by Factor Xa
b. Fibrinogen is converted to fibrin by thrombin
c. Factor XIIIa forms crosslinking on firbin molecules
d. Tissue plasminogen activator (tPA) catalyzes hydrolysis of fibrin

Answer 17

d

Question 18

Which is responsible for degradation of formed clots?
A. von Willebrand factor 
B. Fibrinogen 
C. Plasmin 
D. Heparin

Answer 18

C

Question 19

Which of the following statements is/are true?

a. Factors I, II, VII, and XI are vitamin K independent
b. All vitamin K­dependent factors have gammacarboxyglutamate, which facilitates binding of calcium ions
c. Vitamin K immediately reverses the toxicity caused by warfarin
d. Both B and C

Answer 19

b