Hemostasis

Question 1

What are the “three A’s” that describe platelet actions when forming the temporary platelet plug (primary hemostasis)

Answer 1

1. Adhesion
2. Activation
3. Aggregation

Question 2

Secondary hemostasis strengthens and reinforces the primary plug with a fibrin mesh. This fibrin mesh is formed during….

Answer 2

The coagulation cascade

Question 3

What is the ultimate goal of the coagulation cascade

Answer 3

Activate thrombin, which converts fibrinogen to fibrin

Question 4

3 pathways of the coagulation cascade

Answer 4

Intrinsic
Extrinsic
Common

Question 5

What is the primary pathway for the initiation of coagulation

Answer 5

Extrinsic pathway (tissue factor pathway)

Question 6

Tissue factor (lll) is exposed by disrupted endothelium, and activates factor __________, which then activates factor ________, and then feeds into the common pathway

Answer 6

Vll
X

Question 7

Which pathway is triggered when blood comes in contact with negatively charged surfaces

Answer 7

Intrinsic (contact activation)

Question 8

Which pathway plays only a minor role in initiating clot formation, so deficiencies in it’s factors do not cause a bleeding disorder

Answer 8

Intrinsic (contact activation)

Question 9

What platelet count indicates spontaneous bleeding

Answer 9

Less than 30,000/ uL

Question 10

What is a normal platelet count

Answer 10

200,000 to 500,000/ uL