Hemostasis

Question 1

Which factors release from Weibel-Palade bodies of endothelial cells?

Answer 1

Von Willebrand factor
P-selectin

Question 2

What is the first step of primary hemostasis?

Answer 2

Transient vasoconstriction of damaged vessel

Question 3

vWF binds exposed subendothelial cells, and platelets bind vWFs via their ….. receptor for platelet adhesion.

Answer 3

GP1b

Question 4

The most common overall symptom seen in primary hemostasis disorders?

Answer 4

Epistaxis

Question 5

What is the most common cause of thrombocytopenia in chidren and adults? And its mechanism?

Answer 5

ITP (Immune thrombocytopenic purpura). IgG antibodies against platelet antigens.

Question 6

What is the symptom that is seen at quantitative disorders of platelets and not qualitative disorders?

Answer 6

Petechiae ( 1-2mm)

Question 7

Name 3 disorders that microangiopathic hemolytic anemia is seen?

Answer 7

TTP (thrombotic thrombocytic purpura)
HUS (hemolytic uremic syndrom)
DIC (disseminated intravascular coagulation)

Question 8

TTP and HUS effects especially Renal and CNS. Which is more common in which?

Answer 8

TTP-CNS
HUS-renal

Question 9

What are qualitative platelet disorders ?

Answer 9

1.Bernard Solier (GP1b deficiency)
2.Glanazmann thrombastenia (GP2b/3a deficiency)
3.Aspirin
4.Uremia