hemopoetic system Flashcards
stages of erythropoesis
primitive stem cell— homeopathic stemcell —cfu –proetrroblast –early normobest– intermediate normoblast—late normoblast —reticulocyte —erythrocyte
proetrhroblast
20 micro large nucleus
early normoblast
15 micro nuleioli disapper
intermediate normoblast
10-12 micro small pin point nucleus
late normoblast
8micron size and nucleus disappears
reticulocyte
normally 2-6%
if more than 10% hemolytic anemia
factors affecting erythropoiesis
b12 intrinsic factor ethrythropetin
thyroxine follicular acid
factors affecting formation of hb
iron , copper cobalt 1st class protein in milk and egg
blood group
a. – antigen A antibody b –2.5%
b antigen b antibody a 2.5%
ab antigen ab antibody nil –5%
o antigen -nil antibody ab –45%
blood group uses
blood transfusion criminal check parental check
clotting factors 13 factor
1.fibrinogen
2.prothrombin
3.thrmboplastin
4.calcium
5 labile factor
6 name not known
7 stable factor
8 anti hemophilia factor
9 Christmas factor
10 staurt factor
11 plasma thromboplastin anticident
12 hegman factor
13 fibrin stabilizing factor
3 steps of coagulation
1 vasoconstriction
2 platelate plug formation
3 coagulation cascade
steps of cascade coagulation
1..formation of prothrombin activator (thromboplastin)by intrinsic extrinsic mechanism
2..conversion of prothrombin to thrombin
3..conversion of soluble fibrinogen into insoluble fibrinogen
bt and CT
bt time –3to 6 min
CT time -3to 8 min
prothrombin time 15 sec
leucocyte and platlate
4000-11000
