Hemoglobin 2 11.19.12 Flashcards
1
Q
What is the T state?
A
Deoxygenated Hb?
2
Q
What is The R state?
A
Oxygenated Hb?
3
Q
What is the difference between Oxy and Deoxyhemoglobin in its quarternary struvture
A
the A1B2 or A2B1 interfaces remain immmobile in
the A1B1 rotate 15 degrees relative to A2B2 in going form T state to R state
4
Q
What are deoxygenated moleucle constrained by?
What happens when they are oxygenated
A
Salt linkages between different chains
Salt links between different subunits in deoxyhemoglbin
Noncovalent, electrostatic cross-links are disrupted on oxygenation
Noncovalent, electrostatic cross-links are disrupted on oxygeantion
5
Q
What does deoxygenated molecule bind CO2
A
in teh form of carbamate and H+
contribute to tformaiton fo salt linkages
