Hemoglobin 1.2 Flashcards
What are the two globin chains in the alpha form?
zeta and alpha
What chromosome has gene for alpha globin chains
16
What are the genes on the alpha chain
How many alleles responsible for alpha chain?
zeta alpha alpha (on each chromosome)
4 total alleles/loci (two from each chromosome)
What globin chains belong to Beta forms
epsilon G-gamma G-alpha delta Beta
What chromosome has gene for beta chain
Chromsome #11
What is the gene cluster that encodes the alpha chain of human Hb
zeta, psi-zeta-; psi-alpha2; psi-alpha1; alpha2, alpha1, theta
What is the gene cluster that encodes the beta chain of human Hb
G-Gamma, A-gamma, psi beta, delta, beta
How many exons and introns per gene
3 exons
2 introns
Hb A1
alpha2, beta2
Hb A2
Alpha2, delta2
HbF
alpha2, gamma2
Hb Gower 1
zeta2, epsilon2
Hb Gower 2
alpah2, epsilon2
Hb Portland
zeta2, gamma2
Which chains are present at britha nd quickly decline up to 6months
Zeta and Epsiolon
which globin chain is at its peak at 6 months
beta chains
which rises after first tirimester then declines after birth?
gamma chain
which chain increses after first tirmester and is steady in adult life
alpha
which globin chain appears only after birth and is seen in HbA2
delta
which chain decreases at birth? Increases?
beta chain increaess
gamma chain decreases
What chromosome is the gene for Mb ?
22
How many identities (identical) between BETA and DELTA
138
Identities between Beta and Gamma
108
Between Beta and Alpha
65