Hemmer der Proteinsynthese- Lincosamide Flashcards

1
Q

Lincosamide

A
  • Lincomycin,
  • Clindamycin
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2
Q

Wirkmechanismus:

A
  • bindet an 50S-Untereinheit der Ribosomen
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3
Q

Wirkspektrum:

A
  • grampositive und gramnegative aerobe Erreger,
  • anaerobe gramnegative Erreger,
  • darunter Pneumo-, Strepto-, Staphylokokken,
  • Corynebacterium diphtheriae,
  • Bacteroides fragilis,
  • Clostridium perfringens
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4
Q

Resistenzen:

A
  • Enterobakterien,
  • Pseudomonas,
  • Entero-, Meningo Gonokokken,
  • Haemophilus influenzae,
  • Mycoplasmen,
  • Listerien
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5
Q

Indikationen:

A
  • Peritonitis,
  • Osteomyelitis,
  • HNO-,
  • Zahn-,
  • Kiefer-,
  • Atemwegs- und
  • Weichteilinfektionen
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6
Q

Nebenwirkungen:

A
  • pseudomembranöse Colitis,
  • Übelkeit,
  • Erbrechen,
  • Diarrhoe,
  • allergische Hautreaktionen,
  • Thrombophlebitis bei i.v.-Anwendung
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7
Q

Kontraindikationen:

A
  • Schwangerschaft und Stillzeit,
  • CAVE bei Myasthenia gravis
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