HemeOnc Disease State Descriptions

Question 1

Condition of bone marrow failure that arises from injury to or suppression of the hematopoietic stem cell; pancytopenia develops

Answer 1

Aplastic anemia

Question 2

Megaloblastic anemia with macro-ovalocytes and hypersegmented neutrophils

Answer 2

B12 or Folate Deficiency Anemias

Question 3

Hereditary enzyme defect that causes episodic hemolytic anemia because of the decreased ability of RBCs to deal with oxidative stress

Answer 3

G6PD deficiency anemia

Question 4

Accelerated RBC destruction

Answer 4

Hemolytic anemia

Question 5

Autosomal recessive disorder in which abnormal Hgb leads to chronic hemolytic anemia with numerous consequences

Answer 5

Sickle cell anemia

Question 6

Hereditary disorders characterized by reduction in the synthesis of globin chains

Answer 6

Thalassemias

Question 7

Acquired myeloproliferative bone marrow disorder that causes overproduction of all three cell lines

Answer 7

Polycythemia vera

Question 8

Malignancy of the hematopoietic progenitor cell: cells proliferate in an uncontrolled fashion and replace normal bone marrow elements; happens abruptly

Answer 8

Acute leukemia

Question 9

Myeloproliferative disorder characterized by overproduction of myelooid cells

Answer 9

CML

Question 10

Clonal malignancy of B lymphocytes

Answer 10

CLL

Question 11

Heterogenous group of cancers of lymphocytes that usually present as enlarged lymph nodes

Answer 11

Non-Hodgkin lymphoma

Question 12

Lymphocytic malignancy characterized by reed-sternberg cells

Answer 12

Hodgkin’s Lymphoma

Question 13

Malignancy of hematopoietic stem cells terminally differentiated as plasma cells

Answer 13

Multiple myeloma

Question 14

Congenital deficiency of coagulation factor VIII

Answer 14

Hemophilia A

Question 15

Congenital deficiency of coagulation factor IX

Answer 15

Hemophilia B

Question 16

Congenital deficiency of coagulation factor XI

Answer 16

Hemophilia C

Question 17

Autoimmune condition in which pathogenic antibodies bind platelets, resulting in an accelerated platelet clearance

Answer 17

Immune Thrombocytopenia

Question 18

Thrombocytopenia and microangiopathic hemolytic anemia in the absence of another plausible explanation

Answer 18

Thrombotic Thrombocyoptenic Purpura

Question 19

Quantitative abnormality of vWF

Answer 19

vWF disease Type 1

Question 20

Qualitative abnormality of vWF

Answer 20

vWF disease Type 2A or 2B

Question 21

Defect in vWF that decreases binding to platelets

Answer 21

vWF disease Type 2M

Question 22

Defect in vWF that decreases binding to F. VIII

Answer 22

vWF disease Type 2N

Question 23

Undetectable levels of vWF

Answer 23

vWF disease Type 3