heme onc Flashcards
neutrophilic state after corticosteroids (or increased cortisol during cushings)
increased apparent neutrophils due to release from marginated pool
when theres a left shift, i.e. during infection, what marker is decreased
cd16 (binds Fc of IgG)
hemaopoietic stem cell marker
cd34
whats the cell state in digeorge
no thymus = no t cells = leukopenia
basophilia
CML
leukocytosis vs lymphocytosis
increase in wbc–> seen in infection
lymphocytosis –> increase in lymphocytes, i.e CD8 cells for viral infection
the one bacteria that can cause lymphocytosis (increased)
bordatella pertussis
LN cortex
B cells
LN paracortex
T cells. i.e. EBV infection this increases
periarterial lymphatic sheet (PALS)
white pulp of spleen. around the arteries. this is where t cells are preent. this area will eb expanded during infection i.e. EBV
ALL (LymphoBLASTIC so its a Precursor B/T leukemia): B vs T (can only diff by immunotyping)
(vs AML = MPO +, Auer Rods)
all are TdT+ (and PAS +)
Precursor T: CD1, CD2, CD3, CD5, CD8
Precursor B: CD19, CD10
CD5 is a ______ - cell marker, but can also be seen with ________ (a _____ cell neoplasm)
CD5 = T-cell marker
however, SLL/CLL = CD20+, CD5+ B cell neoplasm (so expresses B cell marker and co-expresses T cell marker on surface)….smudge cells
point mutations in splice sites and promoter regions
Beta thalassemia (decreased beta-globin production)
Severe anemia requiring frequent blood transfusions in ___ - ______ leads to _____________
beta-thalassemia
leads to HEMOCHROMATOSIS–>need iron chelation therapy to reduce load
What happens to marrow in beta thalassemia
Since you have anemia, get
- marrow expansion (crew cut skull, chipmunk facies)
- extramedullary hematopoiesis (hepatosplenomegaly) = increase risk Parvo B19 induced APLASTIC CRISIS
