Heme/Onc

Question 1

Prevents platelets from adhering to fibrin and each other Reserved for this with intolerance to ASA Requires close CBC monitoring

Answer 1

Ticlodipine

Question 2

-Pernicious Anemia MC cause of this anemia. Can be seen in vegans, those s/p gastric surge, and with metformin use -Sx: smooth toungue, glossitis, cheilosis, stocking glove parasethias, dementia -Tx: IM or QD pill

Answer 2

Vit. B12 Anemia

Question 3

Autoimmune hemolytic anemia

Answer 3

Direct Coombs

Question 4

Deficiencies/inhibitor sof intrinsic pathway Used in heparin mangement

Answer 4

aPTT (activated partial thromboplastin time)

Question 5

Prevents platelets from adhering to fibrin and each other Antiplatlet

Answer 5

Clopidogrel (Plavix)

Question 6

-Poor dietary intake, pregos, ETOH abuse, certain meds -Sx: Glossitis, vague GI symptoms, NO neuro sxs -Hypersegmented PMN=pathognomonic -Tx: QD

Answer 6

Folate Deficiency Anemia

Question 7

Manual differentiation

Answer 7

Peripheral blood smear

Question 8

-Vitamin K antagonist -Anticoagulant

Answer 8

Warfarin

Question 9

Prevents fibrin formation. Increases inactivation of coag factors Anticoag

Answer 9

Heparin

Question 10

Increases antithrombin activity, inhibits thrombin and factor Xa Anticoag

Answer 10

Low Molecular Weight Heparin

Question 11

Increased clotting time suggests deficiencies or inhibitors Extrinsic pathway Norm 12.7-15.4

Answer 11

PT (prothrombin time)

Question 12

-MC Anemia -GI loss 2/2 PUD, NSAIDS, CA -Pallor, fatigue, tachycardia, exertional tachypnea -Tx: Iron Sulfate with vit. c for absorption

Answer 12

Fe Deficiency Anemia

Question 13

Tranfusion capatability

Answer 13

Indirect Coombs

Question 14

Essential or 2nd Can result in thrombosis Tx: Hydroxyurea

Answer 14

Thrombocytosis

Question 15

Increased value=slower clotting. Is pt’s PT/average normal PT Normal 0.9-1.1. Warfain rage 2-3

Answer 15

INR

Question 16

-Decreases platlet aggregation -Antiplatelet

Answer 16

ASA

Question 17

-Mild: 100k-150k, Mod. (surgical concern) 50k-100k, severe

Answer 17

Thrombocytopenia