✅heme/onc

Question 1

Spinal Cord Compression can be from DJD, Epidural Abscess or Tumor

Which Cancer metastasis are associated with Tumor Spinal Cord Compression? - 5

Answer 1

1. Prostate
2. Renal
3. Lung
4. Breast
5. Multiple Myeloma

Question 3

cp for Multiple Myeloma - 5

Answer 3

CRABB

(hyperCalcemia, Renal failure, Anemia, Bone lytic lesions, Back pain)

Hypercalcemia –> Bone lytic lesions, CONSTIPATION, Depression

Renal failure from Bence Jones proteinuria and Immunoglobulins –> DEATH

Infection –> DEATH

Osteoclast Activating Factor -> Hypercalcemia and Bone fxs

Question 4

Multiple Myeloma MOD

Answer 4

abnml proliferation of plasma cells that produce useless immunoglobulin (IgG , IgA) –> [Osteoclast Activating Factor] and CRABB (hyperCalcemia, Renal failure, Anemia, Bone lytic lesions, Back pain)

When MM produces IgM = Waldenstrom Macroglobulinemia

Question 6

Multiple Myeloma dx - 5

Answer 6

1. Xray showing osteoLYTIC fx lesions from hypercalcemia
2. Serum Protein Electrophoresis showing IgG or IgA monoclonal “M” Spike (can also be seen in MGUS)
3. Bence Jones proteinuria via urine immunoelectrophoresis only
4. Rouleaux on smear
5. ***Bone marrow bx showing > 10% plasma cells*** = CONFIRMATION