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Pharmacology > Heme Malignancy > Flashcards

Heme Malignancy Flashcards

1
Q

Gemtuzumab Ozogomycin

A

ADC, CD33

Indication - favorable risk AML

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2
Q

Luspatercept

A

TGFB through SMAD 2/3 inhibition

Ind: MDS, RArs / SF3B1 mutation

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3
Q

Azacitidine / Decitabine

A

HMA - epigenetic modification

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4
Q

Fedratinib

A

Selective JAK2 inhibitor

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5
Q

Pacritinib

A

indication- MF
JAK2, FLT3, IRAK

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6
Q

What is a unique AE of fedratinib?

A

Wericke’s encephalopathy (via decreased thiamine uptake)

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7
Q

Ruxolitinib

A

JAK1/2 inhibitor

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8
Q

Rituximab

A

CD20 - activates compliment mediated destruction

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9
Q

Ibritumomab tiuxetan

A

ADC
CD20
FL ( low marrow involvement)

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Pharmacology (6 decks)

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