Hematology Flashcards

1
Q

Crizanlizumab

A

P selection inhibition
Indication: refractory SCD pain crises

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2
Q

Voxalitor

A

Increases Hb oxygen affinity
Indication: refractory pain crises in HbSS

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3
Q

Efgartigimod

A

Inhibits Fc receptor -> increases antibody clearance

Indication - refractory ITP

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4
Q

Fostamatinib

A

MOA - syk inhibition
INDICATION - refractory ITP

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5
Q

FEIBA

A

Indication hemophilia A w/ inhibitor

Functionally an aPCC with VIIIa

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6
Q

Activated r VIIa

A

Indication - hemophilia a or B with inhibitor

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7
Q

Emicizumab

A

MOA - complexes IXa with X (pseudo tenase)

INDICATION - ppx fox hemophilia A

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8
Q

Eculizumab

A

Terminal c5 inhibitor

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9
Q

Ravulizumab

A

Long acting c5 inhibitor

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10
Q

Deferiprone AE

A

Agranulocytosis

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11
Q

Deferasirox AE

A
  • renal failure and GI upset
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