Heme FA Flashcards

1
Q

Four causes of microcytic anemia

A

Thalassemia, Iron deficiency, Anemia of Chronic Disease, Sideroblastic anemia

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2
Q

Diagnostic tests for elderly man with hypochromic, microcytic anemia. Asymptomatic

A

FOVT and sigmoidoscopy for colorectal cancer

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3
Q

Most common cause of inherited hypercoagulability

A

Factor V Leiden

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4
Q

Most common inherited bleeding disorder

A

von Willebrand’s

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5
Q

Most common inherited hemolytic anemia

A

Hereditary spherocytosis

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6
Q

Diagnostic test for hereditary spherocytosis

A

Osmotic fragility test

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7
Q

Pure RBC aplasia

A

Diamond-Blackfan anemia

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8
Q

Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, pancytopenia

A

Fanconi’s anemia

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9
Q

Med and virus that leads to aplastic anemia

A

Chloramphenicol, sulfonamides, radiation, HIV, chemotherapeutic agents, hepatitis, parovirus B19, EBV

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10
Q

How to distinguish polycythemia vera from secondary polycythemia

A

Both have inc hct and RBC mass, vera has normal O2 sat and low epo levels

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11
Q

TTP pentad

A

“FRANT”: fever, renal dysfunction, anemia, neurologic abnormalities, thrombocytopenia

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12
Q

HUS triad

A

anemia, thrombocytopenia, acute renal failure

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13
Q

Treatment for TTP

A

Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs. Platelet transfusion is contraindicated

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14
Q

Treatment for ITP in kids

A

usually resolves spontaneously. May require IVIG and/or corticosteroids

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15
Q

What is inc in DIC? Low?

A

Fibrin split products and D-dimer. Low platelets, fibrinogen, and hct

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16
Q

8 year old male with hemarthrosis and inc PTT with normal PT and bleeding time

A

Hemophilia A or B. Consider desmopressin (hemophilia A) or factor VIII or IX supplements

17
Q

14 year old with prolonged bleeding; normal PT, normal or inc PTT, inc bleeding time

A

vW disease. Treat with desmopressin, FFP, or cryoprecipitate

18
Q

60 year old AA man with bonde pain. Findings of MM?

A

Monoclonal gammopathy, bence jones proteinuria, “punched out” skull and long bone lesions

19
Q

Reed-Sternberg cells

A

Hodgkin’s lymphoma

20
Q

10 year old boy with fever, wt loss, night sweats. Anterior mediastinal mass

A

Non-Hodgkin’s lymphoma

21
Q

Microcytic anemia with low iron, low TIBC, normal or elevated ferritin

A

ACD

22
Q

Microcytic anemia low iron, ferritn and inc TIBC

A

iron deficiency anemia

23
Q

80 year old man with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis

A

CLL

24
Q

Lymphoma equivalent to CLL

A

Small lymphocytic lymphoma

25
Q

Life-threatening complication of CML

A

Blast crisis (fever, bone pain, splenomegaly, pancytopenia)

26
Q

Auer rods on blood smear

A

AML

27
Q

AML subtype associated with DIC treatment

A

M3. Retinoic acid

28
Q

Electrolyte changes in tumor lysis syndrome

A

low Ca, high K, Phos, and uric acid

29
Q

50 year old man with early satiety, splenomegaly, bleeding. t(9,22)

A

CML

30
Q

Heinz bodies

A

intracellular inclusions (thalassemia, G6PD def, post splecetomy