Heme FA

Question 1

Four causes of microcytic anemia

Answer 1

Thalassemia, Iron deficiency, Anemia of Chronic Disease, Sideroblastic anemia

Question 2

Diagnostic tests for elderly man with hypochromic, microcytic anemia. Asymptomatic

Answer 2

FOVT and sigmoidoscopy for colorectal cancer

Question 3

Most common cause of inherited hypercoagulability

Answer 3

Factor V Leiden

Question 4

Most common inherited bleeding disorder

Answer 4

von Willebrand’s

Question 5

Most common inherited hemolytic anemia

Answer 5

Hereditary spherocytosis

Question 6

Diagnostic test for hereditary spherocytosis

Answer 6

Osmotic fragility test

Question 7

Pure RBC aplasia

Answer 7

Diamond-Blackfan anemia

Question 8

Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, pancytopenia

Answer 8

Fanconi’s anemia

Question 9

Med and virus that leads to aplastic anemia

Answer 9

Chloramphenicol, sulfonamides, radiation, HIV, chemotherapeutic agents, hepatitis, parovirus B19, EBV

Question 10

How to distinguish polycythemia vera from secondary polycythemia

Answer 10

Both have inc hct and RBC mass, vera has normal O2 sat and low epo levels

Question 11

TTP pentad

Answer 11

“FRANT”: fever, renal dysfunction, anemia, neurologic abnormalities, thrombocytopenia

Question 12

HUS triad

Answer 12

anemia, thrombocytopenia, acute renal failure

Question 13

Treatment for TTP

Answer 13

Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs. Platelet transfusion is contraindicated

Question 14

Treatment for ITP in kids

Answer 14

usually resolves spontaneously. May require IVIG and/or corticosteroids

Question 15

What is inc in DIC? Low?

Answer 15

Fibrin split products and D-dimer. Low platelets, fibrinogen, and hct

Question 16

8 year old male with hemarthrosis and inc PTT with normal PT and bleeding time

Answer 16

Hemophilia A or B. Consider desmopressin (hemophilia A) or factor VIII or IX supplements

Question 17

14 year old with prolonged bleeding; normal PT, normal or inc PTT, inc bleeding time

Answer 17

vW disease. Treat with desmopressin, FFP, or cryoprecipitate

Question 18

60 year old AA man with bonde pain. Findings of MM?

Answer 18

Monoclonal gammopathy, bence jones proteinuria, “punched out” skull and long bone lesions

Question 19

Reed-Sternberg cells

Answer 19

Hodgkin’s lymphoma

Question 20

10 year old boy with fever, wt loss, night sweats. Anterior mediastinal mass

Answer 20

Non-Hodgkin’s lymphoma

Question 21

Microcytic anemia with low iron, low TIBC, normal or elevated ferritin

Answer 21

ACD

Question 22

Microcytic anemia low iron, ferritn and inc TIBC

Answer 22

iron deficiency anemia

Question 23

80 year old man with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis

Answer 23

CLL

Question 24

Lymphoma equivalent to CLL

Answer 24

Small lymphocytic lymphoma

Question 25

Life-threatening complication of CML

Answer 25

Blast crisis (fever, bone pain, splenomegaly, pancytopenia)

Question 26

Auer rods on blood smear

Answer 26

AML

Question 27

AML subtype associated with DIC treatment

Answer 27

M3. Retinoic acid

Question 28

Electrolyte changes in tumor lysis syndrome

Answer 28

low Ca, high K, Phos, and uric acid

Question 29

50 year old man with early satiety, splenomegaly, bleeding. t(9,22)

Answer 29

CML

Question 30

Heinz bodies

Answer 30

intracellular inclusions (thalassemia, G6PD def, post splecetomy