Heme FA Flashcards
Four causes of microcytic anemia
Thalassemia, Iron deficiency, Anemia of Chronic Disease, Sideroblastic anemia
Diagnostic tests for elderly man with hypochromic, microcytic anemia. Asymptomatic
FOVT and sigmoidoscopy for colorectal cancer
Most common cause of inherited hypercoagulability
Factor V Leiden
Most common inherited bleeding disorder
von Willebrand’s
Most common inherited hemolytic anemia
Hereditary spherocytosis
Diagnostic test for hereditary spherocytosis
Osmotic fragility test
Pure RBC aplasia
Diamond-Blackfan anemia
Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, pancytopenia
Fanconi’s anemia
Med and virus that leads to aplastic anemia
Chloramphenicol, sulfonamides, radiation, HIV, chemotherapeutic agents, hepatitis, parovirus B19, EBV
How to distinguish polycythemia vera from secondary polycythemia
Both have inc hct and RBC mass, vera has normal O2 sat and low epo levels
TTP pentad
“FRANT”: fever, renal dysfunction, anemia, neurologic abnormalities, thrombocytopenia
HUS triad
anemia, thrombocytopenia, acute renal failure
Treatment for TTP
Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs. Platelet transfusion is contraindicated
Treatment for ITP in kids
usually resolves spontaneously. May require IVIG and/or corticosteroids
What is inc in DIC? Low?
Fibrin split products and D-dimer. Low platelets, fibrinogen, and hct