heme externship - heme 1.3-1.4 Flashcards
the osmotic fragility test results in patient with that major would show
A. increased hemolysis
B. decreased hemolysis
C. normal resistance to hemolysis
D. decreased hemolysis after incubation at 37
B. decreased hemolysis
- increased amount of target cells
all of the folliwng ar characteristic findings in a patient with IDA except
A. microcytic hypochromic RBC
B. decreased serum iron and ferritin levels
C. decreased TIBC
D. increased RBC protoporphyrin
C. decreased TIBC
IDA may be distinguished from anemia of chronic infection by
A. serum iron level
B. RBC morphology
C. RBC indices
D. TIBC
D. TIBC
- increased in IDA, decreased in ACI
which anemia has RBC morphology similar to that in IDA
A. sickle cell
B. thal syndrome
C. pernicious anemia
D. HS
B. thal synrome
IDA is characterized by
A. decreased: plasma iron, % sat & increased TIBC
B. decreased: plasma iron, plasma ferritin, nromal RBC porphyrin
C. decreased: plasma iron, % sat, TIBC
D. decreased: plasma iron, TIBC & increased % sat
A.
storage iron is usually best determined by
A. serum transferrin levels
B. hgb values
C myoglobin values
D. serum ferritin levels
D. serum ferritin levels
- serum ferritin is proportional to storage iron
all of the following are associated with sideroblastic anemia except
A. increased serum iron
B. ringed sideroblasts
C. hypochromic anemia
D. decreased serum ferritin
D. decreased serum ferritin
what is the basic hematologigal defect seen in patients with thalassemia major
A. DNA synthetic defect
B. Hgb structure
C. beta chain synthesis
D. hgb phosphorylation
C. beta chain synthesis
- thal major = little to no production of beta chains of hgb
which of the following is the primary hgb in patients with that major
A. hgb D
B. hgb A
C. hgb C
D. hgb F
D. hgb F
a patient has a hct of 30% an hgb of 8 g/dL, RBC of 4.0*10^12. what is the morphological classification of this anemia
(hint: use math)
microcytic hypochromic
- need to calculate MCV and MCHC
- MCV = 75
- MCHC = 26%
in which of the following conditions is hgb A2 elevated
A. hgb H
B. hgb SC disease
C. beta that minor
D. hgb S trait
C. beta thal minor
which of the following parameters may be similar for the anemia of inflammation and IDA
A. normocytic indices
B. decreased serum iron concentration
C. ringed sideroblasts
D. pappenheimer bodies
B. decreased serum iron concentration
- in ACI serum iron is low but ferritin is high
- in IDA serum iron is low and ferritin is low
which morphological classificaiton is cahracteristic of megaloblastic anemia
A. normocytic normochromic
B. microcytic normochromic
C. macrocytic hypochromic
D. macrocytic normochromic
D. macrocytic normochromic
- megaloblastic anemias are a asynchronous development of nuclear maturation
which anemia is characterized by lack of IF that prevents b12 absorption
A. tropical sprue
B. transcobalamin deficiency
C. blind loop syndrome
D. pernicious anemia
D. pernicious
- either antibodies against IF or against IF producing cells
all of the following are characteristics of megaloblastic anemia except
A. pancytopenia
B. elevated retic
C. hypersegmented PMNs
D. macrocytic indices
B. elevated retic
a patient with B12 anemia is prescribed a high dosage of folate. which of the following is expected as a result of this treatment
A. an improvement of neurological problems
B. an improvement of hematological abnormalities
C. no expected improvement
D. toxicity of liver and kidneys
B.
- will improve hematological problems but not neurological, confirms B12 anemiaw
which of the followig disorders is associaed with ineffective erythropoiesis
A. G6PD deficiency
B. liver disease
C. hgb C disease
D. megaloblastic anemia
D. megaloblastic anemia
a 50 yr old is suffering from pernicious anemia. which of the following lab data is most likely for this patient (generally I don’t want to type it all)
A. low RBC, high WBC, normal PLT
B. normal RBC, normal WBC, normal PLT
C. low RBC, normal WBC, high PLT
D. low RBC, low WBC, low PLT
D. pernicious anemia leads to pancytopenia with low RBC, WBC and PLT due to DNA maturation defect impacting all line
which of the following may be seen in the PS from a patient with obstructive liver disease
A. schistocytes
B. macrocytes
C. HJ bodies
D. microcyte
B. macrocytes
- in true megaloblastic conditions they will be oval, in liver issue (not megaloblastic) will be round
the macrocytes typically seen in megaloblastic processes are:
A. crescent shaped
B. teardrop shaped
C. oval shaped
D. pencil shaped
C. oval
which of the following are most characteristic of the RBC indices associated with megaloblastic anemias
A. MCV: 99, MCH 28, MCHC 31%
B. MCV 62, MCH 27, MCHC 30%
C. MCV: 125, MCH 36, MCHC 34%
D. MCV 76, MCH: 23, MCHC: 30%
C. macrocytic normochromic
a patient has 80 nRBCs per 100 leukocytes. in addition to increased polychromasia on the PS what other finding may be present on the CBC
A. increased PLTs
B. increased MCV
C. increased HCT
D. increased RBC count
B. increased MCV
