heme externship 1.7-1.8 Flashcards
repeated phelbotomy in pateints with PV may lead to the development of:
A. folic acid deficiency
B. sideroblastic anemia
C. IDA
D. hemolytic anemia
C. IDA
in ET, the PLTs are:
A. increased in number and functionally abnormal
B. normal in number and functionally abnormal
C. decreased in number ad functional
D. decreased in number and functionally abnormal
A. increased and abnormal
which of the following cells is considered pathognomic for hodgkin disease
A. nieman npick cells
B. reactive lymphocytes
C. flame cells
D. Reedsternberg cells
D. reed sternberg
in myelofibrosis the characteristic abnormal RBC morphology is:
A. target cells
B. schistocytes
C. teardrop
D. ovalocytes
C. teardrop
- due to passage in fibrotic tissue
PV is characterized by
A. increased plasma volume
B. pancytopenia
C. decreased O2 sat
D. absolute increase in total RBC mass
D. absolute increase in total RBC mass
features of secondary polycythemia include all of the following except:
A. splenomegaly
B. decreased O2 sat
C. increased RBC mass
D. increased EPO
A. splenomegally
- characteristic for PV but not secondary
erythrocytosis in relative polycythemia occurs because of:
A. decreased arterial O2 saturation
B. decreased plasma volume of circulating blood
C. increased erythropoietin levels
D. increased erythropoiesis in BM
B. decreased plasma vol
in PV, what is characteristically seen in PS
A. panmyelosis
B. pancytosis
C. pantytopenia
D. panhyperplasia
B. pancytosis
- increase in all cell lines
LAP staining performed on a patient gives the following results:
10(0)
48(1+)
38(3+)
1(4+)
calculate the LAP score
137
LAP = (number of cells of grade x score)
LAP = (48x1)+(38x2)+(3x3)+(1x4)
LAP = 137
CML is distinguished from leukamoid reaction by which of the following
A. CML; low LAP, Leuakmoid; high LAP
B. CML; high LAP, leuk; low LAO
C. CML high WBC, leuk;normal WBC
D. CML; high WBC, leuk; higher WBC
A. CML; low LAP, leukamoid high LAP
which of the following occurs in idiopathic myelofibrosis
A> myeloid metaplasia
B. leukoerythroblastosis
C. fibrosis of BM
D. all of these
D. all of these
what influence does the philidelphia chromosome have on the prognosis of patients with CML
A. it is not predictive
B. the prognosis is better if present
C. the prognosis is worse if present
D. the disease usually transforms into AML when present
B. better prognosis if present
- hybrid gene 9;22
which of the following is (are) commonly found in CML
A. tear drop cells
B. intense LAP stain
C. decrease in granulocytes
D> an increase in basophils
D. increase in basophils
in which of the following conditions does LAP show the least activity
A. leukamoid reactions
B. IMF
C. PV
D. CML
D. CML
a striking feature of PS of a CML pt is
A. bizarre blast cells
B. normal nimner of typical granulocytes
C. presence of granulocytes at different stages
D, pancytopenia
C.
differentiation between CML and AML is the presence of many stages of development of granulocytes in CML whereas AML is only blasts