Heme drugs

Question 1

Heparin- Indications

Answer 1

Prevention of DVTs, treatment of PEs, pregnancy

Question 2

Heparin- MOA

Answer 2

Binds to antithrombin III, inactivates coagulation factors

Question 3

Heparin- AE

Answer 3

hemorrhage, thrombocytopenia, hypersensativity

Question 4

Heparin- Monitoring

Answer 4

Bleeding time

Question 5

LMWH- Indications

Answer 5

Prophylaxis of DVT, MI,

Question 6

LMWH- MOA

Answer 6

Selectively accelerates interaction of antithrombin with factor Xa

Question 7

LMWH- AE

Answer 7

Fewer than heparin, less frequent bleeding,

Question 8

Fondaparinux- Indications

Answer 8

Prophylaxis of DVT, acute PE & DVT in combination with warfarin.

Question 9

Fondaparinux- MOA

Answer 9

Selectivly inhibits factor Xa by selectivly binding to antithrombin III

Question 10

Fondaparinux- AE

Answer 10

Bleeding, no throbocytopenia

Question 11

Warfarin- Indications

Answer 11

Prevention of progression or recurrence of DVT or PE following initial heparin tx. Prophylaxis of MI, a-fib

Question 12

Warfarin- MOA

Answer 12

Antoagonize cofactor function of Vit. K

Question 13

Warfarin- AE

Answer 13

Black box for bleeding, pregnancy, drug-drug interactions

Question 14

Warfarin- Monitoring

Answer 14

INR regularly to adjust dose

Question 15

Dabigatran- Indications

Answer 15

Prevention of stroke, embolism, a-fib. Does not require INR

Question 16

Dabigatran- MOA

Answer 16

Direct thrombin inhibitor

Question 17

Dabigatran- AE

Answer 17

Bleeding, GI, fewer drug-drug interactions than warfarin

Question 18

Rivaroxaban- Indications

Answer 18

Prophylaxis of DVT, stroke, PE

Question 19

Rivaroxaban- MOA

Answer 19

Selective inhibition of factor Xa

Question 20

Rivaroxaban- AE

Answer 20

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, back pain

Question 21

Apixaban- Indications

Answer 21

Prophylaxis of DVT, stroke,

Question 22

Apixaban- MOA

Answer 22

Selectively inhibits factor Xa

Question 23

Apixaban- AE

Answer 23

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, anemia

Question 24

Ticlopidine- Indications

Answer 24

Prevention of TIA, strokes for patient with previous events, with aspirin to prevent thrombus

Question 25

Ticlopidine- MOA

Answer 25

Block platelet aggregation by inhibiting binding of ADP to receptors- prevent platelets from binding to fibrinogen and each other

Question 26

Ticlopidine- AE

Answer 26

hematologic, thrombocytic purpura, aplastic anemia, neutropenia

Question 27

Clopidrel- Indications

Answer 27

Prevention of artherosclerotic events following MI, stroke, peripheral artery disease, prevention of thrombotic events

Question 28

Clopidrel- MOA

Answer 28

Block platelet aggregation by inhibiting binding of ADP to receptors- prevent platelets from binding to fibrinogen and each other

Question 29

Clopidrel- AE

Answer 29

thrombotic throbocytopenic purpura, poor metabolizers,

Question 30

Aspirin- Indications

Answer 30

Prophylaxis of ischemia, MI. Prevention of clotting

Question 31

Aspirin- MOA

Answer 31

Irreversibly inhibits COX 1- reduces prostaglandin, and thrombaoxane. Reduces platelet aggregation

Question 32

Aspirin- AE

Answer 32

Increased bleeding time, GI bleeds