Heme

Question 1

VWD

Answer 1

• mucosal bleeding
• decreased factor VIII, prolonged bleeding time
• treat with ddavp
• AD

Question 2

aplastic anemia

Answer 2

chloramphenicol, carbamezapine, acute hepatitis

Can lead to leukemia

Question 3

polycythemia vera

Answer 3

JAK2 mutation

pruritis following warm showers

Question 4

G6PD

Answer 4

h/o infection, antimalarials, sulfonamides, nitrofurantoin,

• HEINZ bodies
• x linked recessive

Question 5

primary immune thrombocytopenia

Answer 5

child 2-6 YO recent URI
PE petechiae, purpura, gingival bleeding
platelets <100,000
tx-observation, steroids, IVIG

Question 6

multiple myeloma

Answer 6

bence-jones protein
CRAB
hypercalcium
renal insufficiency
anemia
bone lesions

Question 7

spherocytosis

Answer 7

increase MCHC
howell-jolly bodies
osmotic fragility

Question 8

thrombotic thrombocytopenia purpura

Answer 8

elevated LDH, elevated indirect billirubin

tx w/plasma exchange w/steroids

Question 9

sideroblastic anemia

Answer 9

prevents incorporation of Fe into Hg

Question 10

where is B12 absorbed?

Answer 10

terminal ileum

Hypersegmented neutrophils

Question 11

how long do folate stores last?

Answer 11

few month

Question 12

coombs test

Answer 12

AI hemolytic anemia

Question 13

sickle cell

Answer 13

sub of valine for glutamic acid

howell jolly bodies

Question 14

extrinsic measures

intrinsic measures

Answer 14

PT

ptt

Question 15

Hemophilia A/B

Answer 15

increasd PTT

Question 16

VWD

Answer 16

platelet dysfunction
mucous membrane bleeding
increased bleeding time, normal platelet count

Question 17

ITP

Answer 17

petechiae, purpura, decreased platelets**, give steroids

Question 18

TTP

Answer 18

decreased platelets, fever, neuro signs, schistocytes

Question 19

DIC

Answer 19

Increased PT/PTT + d-dimer

decreased fibrinogen, decreased platelets

Question 20

smudge cell

Answer 20

CLL

Question 21

Hodgkin

Answer 21

Reed Sternberg

Question 22

rouleaux

Answer 22

multiple myeloma

Question 23

B12 deficiency

Answer 23

fatigue, peripheral neuropathy
pallor and glossitis
elevated homocysteine and methylmalonic acid

Question 24

Fe def anemia has

Answer 24

increased RDW

Question 25

most people with SS have

Answer 25

renal papillary necrosis

Question 26

if pt has low MCV and it isn’t Fe def, what is it?

Answer 26

thalasemmia minor

Question 27

bone pain, lymphadenopathy, pancytopenia in a kid

Answer 27

ALL

Question 28

when to transfuse platelets

Answer 28

<50,000