Heme Flashcards
VWD
- mucosal bleeding
- decreased factor VIII, prolonged bleeding time
- treat with ddavp
- AD
aplastic anemia
chloramphenicol, carbamezapine, acute hepatitis
Can lead to leukemia
polycythemia vera
JAK2 mutation
pruritis following warm showers
G6PD
h/o infection, antimalarials, sulfonamides, nitrofurantoin,
- HEINZ bodies
- x linked recessive
primary immune thrombocytopenia
child 2-6 YO recent URI
PE petechiae, purpura, gingival bleeding
platelets <100,000
tx-observation, steroids, IVIG
multiple myeloma
bence-jones protein CRAB hypercalcium renal insufficiency anemia bone lesions
spherocytosis
increase MCHC
howell-jolly bodies
osmotic fragility
thrombotic thrombocytopenia purpura
elevated LDH, elevated indirect billirubin
tx w/plasma exchange w/steroids
sideroblastic anemia
prevents incorporation of Fe into Hg
where is B12 absorbed?
terminal ileum
Hypersegmented neutrophils
how long do folate stores last?
few month
coombs test
AI hemolytic anemia
sickle cell
sub of valine for glutamic acid
howell jolly bodies
extrinsic measures
intrinsic measures
PT
ptt
Hemophilia A/B
increasd PTT
VWD
platelet dysfunction
mucous membrane bleeding
increased bleeding time, normal platelet count
ITP
petechiae, purpura, decreased platelets**, give steroids
TTP
decreased platelets, fever, neuro signs, schistocytes
DIC
Increased PT/PTT + d-dimer
decreased fibrinogen, decreased platelets
smudge cell
CLL
Hodgkin
Reed Sternberg
rouleaux
multiple myeloma
B12 deficiency
fatigue, peripheral neuropathy
pallor and glossitis
elevated homocysteine and methylmalonic acid
Fe def anemia has
increased RDW
most people with SS have
renal papillary necrosis
if pt has low MCV and it isn’t Fe def, what is it?
thalasemmia minor
bone pain, lymphadenopathy, pancytopenia in a kid
ALL
when to transfuse platelets
<50,000
