Heme

Question 1

Biosynthesis of heme takes place in

Answer 1

Almost all tissues
Synthesized in normoblast
But not in mature erythrocytes

Question 2

Where does the biosynthesis of purine take place

Answer 2

Partly both
Cytoplasm
Mitochondria

Question 3

Types or forms of alas

Answer 3

Erythroid and hepatic/non erythroid

Question 4

Basic administration of what can help porphyria

Answer 4

Glucose

Question 5

Where is ferrochelatase located

Answer 5

Mitochondria

Question 6

Pyrrole rings joined together by what bridges

Answer 6

Methylene bridges

Question 7

The methylene bridges that connect pyrrole rings are derived from

Answer 7

Alpha carbon of glycine

Question 8

Deficiency of ALAS 2 results in what disorder and why

Answer 8

XLSA

ALAS2 gene on X chromosome. X-linked sideroblastic anemia, XLSA.
Sideroblasts are erythroblasts with non-heme iron-containing organelles, called siderosomes. XLSA has also been called congenital sideroblastic anemia, hereditary sideroblastic anemia, hereditary iron-loading anemia, X-linked hypochromic anemia, hereditary hypochromic anemia, and hereditary anemia.

Question 9

What are sideroblasts

Answer 9

Sideroblasts are erythroblasts with non-heme iron-containing organelles, called siderosomes.

Question 10

What is porphyria

Answer 10

Characterized by increased production and excretion of porphyrins or their precursors (ALA or PBG )

Question 11

Grouping of porphyrias

Answer 11

Hepatic
Erythropoietin
With both abnormalities