Heme

Question 1

how is neutropenia defined?

Answer 1

ANC <1500/mm3

Question 2

Reed-Sternberg cells is indicative of…..

Answer 2

Hodgkin’s lymphoma

Question 3

Bence-Jones protein is indicative of ……

Answer 3

multiple myeloma

Question 4

CRAB in MM

Answer 4

CRAB - hypercalcemia, renal failure (proteinuria), anemia (normocytic), back pain

Question 5

how is thrombocytopenia defined?

Answer 5

platelet count <150,000

Question 6

hemophilia A is caused by ______ deficiency

Answer 6

factor VIII

Question 7

what is hematocrit?

Answer 7

proportion of RBC in 1 mL of plasma

Question 8

what medications can cause B12 deficiency?

Answer 8

antacids
H2RA
PPI x 12 months
metformin x 4 months

Question 9

what are some symptoms of hereditary hemochromatosis?

Answer 9

chronic fatigue, hyperpigmentation (bronze skin), swelling of second and third MCP, joint stiffness

Question 10

what are some medications that can cause impaired folate absorption with long term use?

Answer 10

phenytoin, TMP-SMX, metformin, MTX, sulfasalazine

Question 11

G6PD Deficiency Anemia is ____ linked and (dominant/recessive)

Answer 11

X-linked recessive

Question 12

what are some triggers for hemolysis with G6PD Deficiency anemia?

Answer 12

Drugs: primaquine, hydroxychloroquine, sulfa, acetazolamide, nitrofurantoin, dapsone
Food: fava beans, henna
Fever, infections, stress

Question 13

symptoms of hemolysis with G6PD deficiency anemia?

Answer 13

• 2-4 days after trigger:
Acute onset jaundice, yellow sclerae, pallor, fatigue, SOB, tachycardia, dark urine
Hgb decreased
Elevated serum indirect bili