Hematopoiesis

Question 1

these are features of what cell:

large cell with nucleoli and cytoplasm ranging from neutral to basophilic

Answer 1

proerythroblast

-indistinguishable from myeloblast so call blast in preparation

Question 2

these are features of what cell:

large cell
basophilic cytoplasm
no nucleoli

Answer 2

basophilic erythroblast

Question 3

these are features of what cell:

avg size cell
cytoplasm bn basophilic and eosinophilic

Answer 3

polychromatic erythroblast

Question 4

these are features of what cell:

avg size cell
eosinophilic cytoplasm
nucleus pertruding cell in some

Answer 4

orthochromatic erythroblast

Question 5

these are features of what cell:

small cell 
spherical 
eosinophilic 
lacks nuclei 
remnants of intraceullar organelles visible in blue stain

Answer 5

reticulocyte

Question 6

these are features of what cell:

non nucleated cell
bi concave shape

Answer 6

erythrocyte

Question 7

if we had an actual microscope, what are some afvantages

Answer 7

1. focus
   - helps identify nucleoli and primary/2ndary granules
   - resolution = important in identifying granulocyte precursors
2. adjust light
   - gives better color contrast
   - color = important in identifying erythrocyte precursor

Question 8

these are features of what cell:

large cell
nucleoli’no granules present

Answer 8

myeloblast

-called blast bc can’t distinguish with other

Question 9

these are features of what cell:

smaller cell
nucleoli
azurophilic granules appearing (usually near golgi)

Answer 9

promyelocyte

Question 10

these are features of this general termed cell:

specific granules
round or kidney nucleus

Answer 10

myelocyte

Question 11

what is the difference bn early myelocytes and late myelocytes

Answer 11

early is round nucleus with few specific granules

late is kidney bean shape nucleus with many specific granules

Question 12

these are features of what cell:

V shaped nucleus aka acute angle indent aka pacman

Answer 12

metamyelocyte (neutrophilic or eosinophilic are only 2 that can distinguish on LM)

Question 13

these are features of what cell:

C shaped nucleus
2% present in blood

Answer 13

band cell (neutrophilic)

Question 14

these are features of what cell:

segmented nucleus
granules

Answer 14

mature neutrophil, eosinophil, or basophil depending on granule colors

Question 15

difference between red marrow and yellow marrow

Answer 15

red marrow has mostly hemopoietic cells while yellow marrow has mostly adipocytes

Question 16

how do cells leave the marrow

Answer 16

by entering systemic circulation via marrow sinusoid capillaries

Question 17

what is the stem cell for blood

Answer 17

PHSC pluripotential hematopoietic stem cell

Question 18

what granules contain cethespins and gelatinases that break down CT elements to facilitate cell migration

Answer 18

tertiary granules

Question 19

macrophages are sequestered in the

Answer 19

spleen

Question 20

neutrophils are sequestered in the

Answer 20

peripheral capillaries in the marginal pool

Question 21

lymphocytes are sequestered in

Answer 21

lymphatic organs

Question 22

control of hemopoiesis is exerted by what

Answer 22

chemokines that act on the progenitor population

they’re called colony stimulating factors

Question 23

what is the easiest hematopoietic cell to recognize in marrow

Answer 23

megakaryocyte

Question 24

what do megakaryocytes produce

Answer 24

platelets

Question 25

what are proplatelet strings

Answer 25

extensions of the megakaryocytes cytoplasm into the sinus lumen

Question 26

what cell type generates all cell types through mitosis and differentiation, and can renew themselves through mitosis

Answer 26

stem cells

Question 27

what cells generate a strict lineage through mitosis and can make themselves

Answer 27

progenitor cells

Question 28

what cells are restricted to a single lineage, could still go through mitosis, but can’t make themselves

Answer 28

precursor cells