Hematopoiesis Flashcards
A continuous, regulated process of blood cell production
Hematopoiesis
Cell blood production includes? (4)
- Cell Renewal
- Proliferation
- Differentiation
- Maturation
3 Hematopoietic development
- Post Natal Development
- Fetal Development
- Post Natal Development
3 Phases of Pre-Natal Development
- Mesoblastic Phase
- Hepatic Phase
- Myeloid Phase
Mesoblastic Phase is also known as?
Primitive Phase
Mesoblastic Phase Begins at?
19th Day after Fertilization
Chief site of Mesoblastic Phase?
Yolk Sac
First cells to be found in the Yolk Sac and where does it arise from?
Primitive Erythrocytes / Mesodermal Cells
3 Embryonic Hemoglobin?
- Gower 1
- Gower 2
- Portland
At what phase does Alpha Globin Chain Begins?
Mesoblastic Phase
Gower 1 Globin Chain Combination
2 Epsilon 2 Zeta
Gower 2 Globin Chain Combination
2 Alpha 2 Epsilon
Portland Globin Chain Combination
2 Zeta 2 Gamma
Hepatic phase is also known as?
Definitive Hematopoiesis
Hepatic Phase chief site
Liver
Hepatic phase begins at?
5-7 Gestational Weeks
What developing organs contribute to the Hepatic Phase? (4)
- Thymus
- Spleen
- Kidney
- Lymph Nodes
Major Site for T Cell Production
Thymus
Organs that produces B Cells (2)
- Kidney
- Spleen
Embryonic Hemoglobin will be converted into what Hemoglobin? (2)
- Hemoglobin F
- Hemoglobin A
Hemoglobin F Globin Chain Combination
2 Alpha 2 Gamma
Myeloid Phase is also known as?
Medullary Phase
When does Medullary Phase Start?
4th and 5th Month of Fetal Development
Chief Site of Medullary Phase
Bone Marrow
Myeloid to Erythroid Ratio
3:1
Glycoproteins that are responsible for stimulation and Production of RBCs
Erythropoietin
Type of Growth Factor
Granulocyte-Colony Stimulating Factor
Stimulates the production of Granulocyte, Monocyte and Macrophage
GM-CSF (Granulocyte Macrophage CSF)
Hemoglobin A Globin Chain Combination
2 Alpha 2 Beta
Hemoglobin A2 Globin Chain Combination
2 Alpha 2 Delta
Cells for the production if Granulocyted
Myeloid
Lymphoid Tissue where T and B Lymphocytes are derived
Primary Lymphoid Tissue