Hematopoiesis Flashcards
came from hematopoietic stem cell
HEMATOPOIETIC CELLS
Explain stem cycle kinetics
The bone marrow is estimated to be capable of
producing approximately:
• 2.5 billion erythrocytes
• 2.5 billion platelets
• 1 billion granulocytes per kilogram of body
weight daily.
The determining factor controlling the rate of
production is ___________?
Physiologic needs
What is the role and function of cytokines?
regulate the proliferation,
differentiation, and maturation of hematopoietic
precursor cells.
Not a regulator of the RBC but a regulator of the
precursor cells.
Cytokines
Why is classification difficult in cytokines?
Classification is difficult due to overlapping and
redundant properties
What is the role and function of: COLONY-STIMULATING FACTORS?
o Produced by many different cells
o High specificity for target cells
o Active at low concentrations
stimulates granulocyte and monocyte
progenitor proliferation’
GM-CSF
stimulates granulocyte and monocyte
progenitor proliferation’
GM-CSF
What does GM-CSF stimulate?
Granulocyte and monocyte
COLONY-STIMULATING FACTORS works synergistically with _______ to enhance
megakaryocyte colony formation
IL-3
known for proliferating
IL-3
What is the role and function of Early-Acting Multilineage Growth Factors?
Activation of the KIT Receptor by the KIT
ligand is essential in the early stages of
hematopoiesis
regulates blood cell production of
granulocytes and macrophages
IL-3
first IL to release temperature if
there is infection
IL-1 (Pyrokinetic IL)
