HEMATOPOIESIS Flashcards
Process of blood production (building up of blood components– RBC, WBC, and platelets)
Hematopoiesis
INTRAUTERINE HEMATOPOIESIS PHASES (3)
Mesoblastic Phase
Hepatic Phase
Myeloid/ Medullary Phase
YOLK SAC
Mesoblastic Phase
LIVER
Hepatic Phase
RED BM
Myeloid/ Medullary Phase
Mesoblastic Phase Begins at
19th day of gestation
Hepatic Phase Begins at
6 weeks of gestation
Myeloid/ Medullary Phase Begins around
5th month of gestation
first cell and doesn’t disappear even until adulthood
Primitive Nucleated Erythroblast
Embryonic Hgb (3)
- Gower I
- Gower II
- Portland
Production of red blood cells, granulocytes, monocytes, and megakaryocytes
Hepatic Phase
Alpha and gamma globin chain production (HbF)
Hepatic Phase
Bone marrow producing mainly granulocytes
Myeloid/ Medullary Phase
6th months of age gamma-beta globin chain switch
Myeloid/ Medullary Phase
80-90% of bone marrow is ACTIVE BONE MARROW
Newborn
60% of bone marrow is ACTIVE
Young Adult (Age 20)
Older Adult: ___ bone marrow is ACTIVE AND ___ is FAT
40% ; 60%
it is the ratio of marrow cells to fat (red marrow/yellow marrow)
CELLULARITY
marrow has 30-70% hematopoietic cells
Normocellular
marrow has >70% hematopoietic cells
Hypercellular/ Hyperplastic
marrow has <30% hematopoietic cells
Hypocellular/ Hypoplastic
marrow has few or no hematopoietic cells
Aplastic
It is the ratio of granulocytes and their precursors to nucleated erythroid precursors
M:E (Myeloid: Erythroid) Ratio
Normal M:E Ratio
3:1 or 4:1
_____ and _____ are excluded from the M:E ratio
Lymphocytes and monocytes
simply counting the # of types of WBC
Differential Count Smear
special request to identify RBC morphology, especially blast cells
PBS
Contains both alpha and beta polypeptide chain
globin
semi-permeable so electrolytes can pass through
Cell membrane
