ANEMIA DUE TO IMPAIRED OR DEFECTIVE PRODUCTION OF ANEMIAS Flashcards
MOST COMMON FORM OF ANEMIA (DOH)
Iron Deficiency Anemia (IDA)
Iron Deficiency Anemia (IDA) IS ________ ANEMIA
Microcytic/ hypochromic anemia
Iron Deficiency Anemia (IDA) is low in (5)
Serum iron, ferritin, hemoglobin/ hematocrit, RBC indices, reticulocyte count
Iron Deficiency Anemia (IDA) is high in (2)
RDW (variations in RBC sizes) and TIBC
Inability to use available NORMAL red blood cells
Anemia of Chronic Dse (ACD)
impaired release of storage iron associated with
increased HEPCIDIN levels
Anemia of Chronic Dse (ACD
Anemia of Chronic Dse (ACD) IS ______ anemia, or slightly _____ anemia
Normocytic/ normochromic anemia, or slightly microcytic/ hypochromic anemia
Anemia of Chronic Dse (ACD) is associated with
Associated with persistent infections, chronic inflammatory disorders (arthritis, gout)
Anemia of Chronic Dse (ACD) is
Increased in
Decreased in
INC: Ferritin and serum iron
DEC: TIBC
Is an INHERITED blood disorder that causes your body to have less hemoglobin than normal
Thalassemia
Multiple blocks in the protoporphyrin pathway
Lead Poisoning
Lead Poisoning is a _________ anemia with characteristic of what stippling?
Normocytic/ normochromic anemia ;course basophilic stippling
Group of INHERITED disorders characterized by a block in the protoporphyrin pathway
Porphyrias
In Porphyrias, Heme precursors before the block accumulate in the tissues, and large amounts are excreted in ______
urine/feces
● Photosensitivity, abdominal pain, CNS disorders
● Hematologic findings are insignificant
Porphyrias
Defective DNA synthesis causes abnormal NUCLEAR MATURATION; RNA synthesis is normal, so the cytoplasm is not affected
Megaloblastic Anemias
Nucleus matures slower than the cytoplasm (asynchronism)
Megaloblastic Anemias
Megaloblastic Anemias is caused by either ____ or _____
Vitamin B12 deficiency or folic acid deficiency
Hypoproliferative anemia caused by replacement of bone marrow hematopoietic cells by malignant cells or fibrotic tissue
Myelophthisic (Bone Marrow Replacement) Anemia
Myelophthisic (Bone Marrow Replacement) is _______/_____ anemia
Normocytic/ Normochromic anemia
Bone marrow failure
Aplastic anemia
Aplastic anemia is decreases in
Hemoglobin/ hematocrit and reticulocytes
Aplastic anemia is ______/_______ anemia
Normocytic/ Normochromic anemia
● Caused by blocks on the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload
● Excess iron accumulates in the mitochondrial region of immature erythrocytes (ringed sideroblasts)
Sideroblastic anemia
In sideroblastic anemia, ____ rbc population (_____) are seen
Two; dimorphic
Sideroblastic anemia
INC
DEC
INC: Ferritin and serum iron
DEC: TIBC
