ANEMIA DUE TO IMPAIRED OR DEFECTIVE PRODUCTION OF ANEMIAS

Question 1

MOST COMMON FORM OF ANEMIA (DOH)

Answer 1

Iron Deficiency Anemia (IDA)

Question 2

Iron Deficiency Anemia (IDA) IS ________ ANEMIA

Answer 2

Microcytic/ hypochromic anemia

Question 3

Iron Deficiency Anemia (IDA) is low in (5)

Answer 3

Serum iron, ferritin, hemoglobin/ hematocrit, RBC indices, reticulocyte count

Question 4

Iron Deficiency Anemia (IDA) is high in (2)

Answer 4

RDW (variations in RBC sizes) and TIBC

Question 5

Inability to use available NORMAL red blood cells

Answer 5

Anemia of Chronic Dse (ACD)

Question 6

impaired release of storage iron associated with
increased HEPCIDIN levels

Answer 6

Anemia of Chronic Dse (ACD

Question 7

Anemia of Chronic Dse (ACD) IS ______ anemia, or slightly _____ anemia

Answer 7

Normocytic/ normochromic anemia, or slightly microcytic/ hypochromic anemia

Question 8

Anemia of Chronic Dse (ACD) is associated with

Answer 8

Associated with persistent infections, chronic inflammatory disorders (arthritis, gout)

Question 9

Anemia of Chronic Dse (ACD) is
Increased in
Decreased in

Answer 9

INC: Ferritin and serum iron
DEC: TIBC

Question 10

Is an INHERITED blood disorder that causes your body to have less hemoglobin than normal

Answer 10

Thalassemia

Question 11

Multiple blocks in the protoporphyrin pathway

Answer 11

Lead Poisoning

Question 12

Lead Poisoning is a _________ anemia with characteristic of what stippling?

Answer 12

Normocytic/ normochromic anemia ;course basophilic stippling

Question 13

Group of INHERITED disorders characterized by a block in the protoporphyrin pathway

Answer 13

Porphyrias

Question 14

In Porphyrias, Heme precursors before the block accumulate in the tissues, and large amounts are excreted in ______

Answer 14

urine/feces

Question 15

● Photosensitivity, abdominal pain, CNS disorders
● Hematologic findings are insignificant

Answer 15

Porphyrias

Question 16

Defective DNA synthesis causes abnormal NUCLEAR MATURATION; RNA synthesis is normal, so the cytoplasm is not affected

Answer 16

Megaloblastic Anemias

Question 17

Nucleus matures slower than the cytoplasm (asynchronism)

Answer 17

Megaloblastic Anemias

Question 18

Megaloblastic Anemias is caused by either ____ or _____

Answer 18

Vitamin B12 deficiency or folic acid deficiency

Question 19

Hypoproliferative anemia caused by replacement of bone marrow hematopoietic cells by malignant cells or fibrotic tissue

Answer 19

Myelophthisic (Bone Marrow Replacement) Anemia

Question 20

Myelophthisic (Bone Marrow Replacement) is _______/_____ anemia

Answer 20

Normocytic/ Normochromic anemia

Question 21

Bone marrow failure

Answer 21

Aplastic anemia

Question 22

Aplastic anemia is decreases in

Answer 22

Hemoglobin/ hematocrit and reticulocytes

Question 23

Aplastic anemia is ______/_______ anemia

Answer 23

Normocytic/ Normochromic anemia

Question 24

● Caused by blocks on the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload
● Excess iron accumulates in the mitochondrial region of immature erythrocytes (ringed sideroblasts)

Answer 24

Sideroblastic anemia

Question 25

In sideroblastic anemia, ____ rbc population (_____) are seen

Answer 25

Two; dimorphic

Question 26

Sideroblastic anemia
INC
DEC

Answer 26

INC: Ferritin and serum iron
DEC: TIBC