Hematopoiesis Flashcards

1
Q

production of all blood cells - continuous process through entire life

A

hematopoiesis

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2
Q

where does hematopoiesis take place in the fetus

A

liver and spleen

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3
Q

where does hematopoiesis take place in adults

A

red bone marrow

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4
Q

less active red bone marrow, mostly fat cells

A

yellow bone marrow

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5
Q

bone marrow sites in most species

A

skull
ribs
sternum
vertebrae column
pelvis
proximal ends of femurs

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6
Q

all blood cell types are derived from a single primitive stem cell typed called what

A

pluripotential or multipotential stem cell

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7
Q

pluripotential or multipotential stem cells have the potential to replicate and differentiate into many different discrete types of what

A

unipotential stem cell

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8
Q

maturation process where unipotential stem cell matures into specific cells

A

erythropoesis (RBC)
leukopoiesis (WBC)
thrombopoesis (platelets)

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9
Q

the process by which red blood cells are created

A

erythropoesis

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10
Q

eventually the erythrocyte (RBC) will lose what and stop what

A

nuclei and multiplying

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11
Q

How long does erythropoiesis take for dogs, cows and birds

A

dog - 1 week
cow - 4 to 5 days
birds - 36 hours

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12
Q

what hormone controls the rate of erythropoesis

A

erythropoietin (EPO)

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13
Q

erythropoietin is produced primarily by what cells

A

cells of the kidney

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14
Q

the production of erythropoietin is regulated by what

A

blood oxygen levels in the kidney

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15
Q

what is the stimulus for increased erythropoietin production

A

hypoxia (low levels of oxygen in your body tissues)

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16
Q

in cases of severe anemia, what may be released

A

nucleated RBCs (NRBCs)

17
Q

nucleated RBCs are immature stages of RBC that retain what

A

their nuclei

18
Q

NRBCs are not fully mature so they aren’t as efficient even though they are producing what

A

some hemoglobin

19
Q

the production of platelets

A

thrombopoiesis

20
Q

large multinucleated cell that never leaves the bone marrow

A

megakaryocyte

21
Q

what part of the megakaryocyte release platelets into peripheral blood

A

pieces of cytoplasm

22
Q

platelets are also known as what

A

thrombocytes

23
Q

thrombopoietin is produced by what

A

liver

24
Q

formation of white blood cells

A

luekopoiesis

25
Q

two classifications of leukocytes

A

granulocytes
agranulocytes

26
Q

production of granulocytes (three types of WBCs)

A

granulopoesis

27
Q

three types of granlocytes

A

neutrophils
eosinophils
basophils

28
Q

two types of agranulocytes

A

lymphocytes
monocytes

29
Q

the process that produces lymphocytes

A

lymphopoiesis

30
Q

the formation of mature monocytes

A

monopoiesis