Hematology Week 2: Lab Testing of Hematologic Neoplasms

Question 1

Lab Tests of Hematologic Neoplasms

7 listed

Answer 1

• Morphology
• Cytochemistry
• Flow Cytometry
• Immunohistochemistry
• Chromosomes
• FISH
• Molecular

Question 2

Which is a blast?

Answer 2

C

Question 3

Question 1

Answer 3

A. Can detect multiple antigens on a single cell

Question 4

How does Flow Cytometry work?

Answer 4

intensity of signal can denote quantity

Question 5

Analyzing Flow Cytometry Results

Question 6

CD45 Expressed by?

Answer 6

all Hematopoietic cells

Question 7

CD19 Expressed by?

Answer 7

B cells

Question 8

CD20 Expressed by?

Answer 8

B cells

Question 9

Kappa Expressed by?

Answer 9

B cells

Question 10

Lambda Expressed by?

Answer 10

B cells

Question 11

CD3 Expressed by?

Answer 11

T cells

Question 12

CD4 Expressed by?

Answer 12

T cells

Question 13

CD5 Expressed by?

Answer 13

T cells

Question 14

CD8 Expressed by?

Answer 14

T cells

Question 15

MPO expressed by?

Answer 15

Myeloid Cells

Question 16

MPO AKA

Answer 16

Myeloperoxidase

Question 17

CD33 Expressed by?

Answer 17

Myeloid Cells

Question 18

CD34 Expressed by?

Answer 18

Immature cells (blasts)

Question 19

TdT Expressed by?

Answer 19

Immature cells (Blasts)

Question 20

Question 2

Answer 20

C

Question 21

TdT AKA

Answer 21

Terminal Deoxytransferase

Question 22

Auer Rod indicates?

Answer 22

• Only arises in myeloid neoplasm
• in abnormal cells fusion of abnormal granules form Auer Rod

Question 23

Immunohistochemistry

Answer 23

Question 24

Question 3

Answer 24

A CD19

Question 25

Question 4

Answer 25

A - B-cell Lymphoma

Question 26

clonality analysis

Answer 26

mixture would be multiple peaks clonal would be strong single peak

Question 27

Question 5

Answer 27

B

Acute Lymphoblastic Leukemia

Question 28

Karyotype important

Answer 28

diagnostically but also prognostically

Question 29

Dual Fusion Fish

Answer 29