Hematology System Flashcards

0
Q

Plasma minus clotting factors

A

Serum

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1
Q

General Function of Blood

A

Vehicle of transport
Regulation of pH and ion composition
Defense
Stabilization

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2
Q

Composition of Plasma

A
Water: 90%
Proteins: 8%
Inorganic salts: 1%
Lipids: 0.5%
Sugar: 0.1%
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3
Q

Essential component of clotting system

A

Blood coagulation proteins

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4
Q

Major contribution to osmotic pressure of plasma

A

Albumin

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5
Q

Proteases, antiproteases, transport protiens

A

Alpha globulin

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6
Q

Transferrin and other transport proteins

A

Beta globulins

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7
Q

Immunoglobulins

A

Gamma globulins

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8
Q

Lifespan of platelets

A

7-10 days

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9
Q

Processing of forming blood cells in the bone marrow

A

Haemopoesis

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10
Q

Site of blood cell formation less than 2months AOG

A

Yolk sac (AORTIC GONAD MESONEPHROS)

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11
Q

Site of blood cell formation from 3rd month AOG to birth?

A

LIVER and spleen

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12
Q

Only source of blood POSTnatally; begins at 4th month AOG

A

Bone marrow

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13
Q

All bone marrow are active

A

Birth to Puberty

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14
Q

Only bone marrow of vertebrae, ribs, sternum, skull, pelvis, proximal epiphyseal region of humerus active

A

Age 20

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15
Q

Post-embryonic extramedullary hematopoiesis in full-term infant

A

Always abnormal

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16
Q

Carbon dioxide attached to Hgb

A

Carbamino hemoglobin

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17
Q

Carbon monoxide attached to Hgb

A

Carboxyhemoglobin

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18
Q

Oxygen attached to Hgb

A

Oxyhemoglobin

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19
Q

Size of. RBC

A

Length: 8um
Width: 2um

20
Q

Hemoglobin values
Male:
Female:

A

Male: 14-18g/dL
Female: 12-18g/dL

21
Q

Normal Hematocrit Values:

A

Male: 46 (40-54)
Female: 42 ( 37-47)

22
Q

How many O2 molecules can 1 hemoglobin molecule bind

A

4 oxygen molecules

23
Q

Hemoglobin A

A

2 alpha and 2 beta

24
Hemoglobin F
2 alpha and 2 gamma
25
Total iron in the body
4-5 grams
26
Iron found in plasma
Transferrin
27
Iron found in LIVER
Ferritin
28
Storage form of iron found outside the liver
Hemosiderin
29
Enzyme responsible in synthesis of Hemoglobin
Amino Levolinic Acid Synthase (ALA synthase)
30
Hormone stimulating RBC production
Erythropoietin
31
Main stimulus for EPO peoduction
Hypoxia
32
Effect of EPO will after this many days
5 days
33
Last RBC stage with a nucleus
Orthochromatic erythroblast
34
RBC stage released to the blood
Reticulocyte
35
Time to convert reticulocytes to mature RBCs
1-2 days
36
Characteristics of mature RBC's
No nucleus No mitochondria No ER
37
Lifespan of adult RBC's
120 days
38
Lifespan of fetal RBC's
90 days
39
Intravascular destruction of old or damaged RBCs occurs here
Spleen
40
Extravascular destruction of RBCs is due to
Macrophages
41
Fate of Heme in destroyed RBC
Bilirubin
42
Nutrient essential for DNA synthesis
Vitamin B12 | Folic acid
43
Megaloblastic anemia + Neural deficits
Vitamin B12 deficiency
44
Megaloblastic anemia + Neural tube disorders
Folic acid deficiency
45
Needed to absorb Vitamin B12
Intrinsic Factor in Terminal Ileum
46
Source of Vitamin B12
Meats
47
Source of Folic acid
Leafy vegetables