Hematology/Lymph Flashcards
Cause of symptoms in sickle cell pts?
sickle cell Hb polymerizes under hypoxic conditions due to amino acid substitution on beta chain
What is glycoprotein IIb/IIIa a receptor for in platelet activation?
fibrinogen
How does cisplatin work?
cross-linking DNA
A pt with hereditary spherocytosis is likely to get what as a result?
pigmented gallstones
What are the leukocytes in hairy cell leukemia stained with?
tartrate-resistant acid phosphatase
Which measurements are affected by tPA?
PT and PTT bc it degrades fibrin and fibrinogen ( both pathways)
What is the microscopic hallmark of Burkitt Lymphoma?
Starry sky (lymphos interspersed w macros)
What are the genetic associations for Burkitt Lymphoma?
c-myc
t(8,14) translocation
In which 3 diseases is erythrocyte sedimentation rate decreased?
polycythemia
CHF
sickle-cell anemia
Which antibiotic decreases the metabolism of warfarin?
ketoconazole
What is Bernard-Soulier syndrome?
Defect in platelet plug formation.
What (3) hallmarks will diagnose Bernard-Soulier syndrome?
- Large platelets.
- GpIb defect in platelet-to-vWF adhesion.
- Abnormal ristocetin cofactor assay.
Which clusters of differentiation (CD) identify Reed-Sternberg cells?
CD 30 and CD15
What differentiates polycythemia vera w reactive polycythemia vera?
reactive = cases of tissue hypoxia (smokers, decreased O2 saturation)
Which translocation is associated with Acute Promyelocytic Leukemia?
t(15;17)
How does aspirin induce antiplatelet effects?
inhibits COX –> inhibits thromboxane A2 (platelets cant aggregate)
Granules in eosinophils will contain which protein?
Major basic protein
Which class of antibiotics can potentiate wrfarin’s effects and cause bleeding?
macrolides (-mycin)
How does streptokinase cause thrombolysis?
Binding to plasminogen = release plasmin
Whats the MOA of ticlopidine?
Inhibits platelet aggregation by preventing adenosine diphosphate from binding to platelet receptors
What is Porphyria cutanea tarda?
Uroporphyrinogen decarboxylase (UROD) deficiency (5th setp in heme synthesis pathway)
What are clinical manifestations of Uroporphyrinogen decarboxylase (UROD) def?
- tea-colored urine
- Blistering cutaneous photosensitivity
(Most common porphyria)
