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USMLE Step 1 > Hematology/Lymph > Flashcards

Hematology/Lymph Flashcards

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USMLE® Step 1 flashcards
1
Q

Cause of symptoms in sickle cell pts?

A

sickle cell Hb polymerizes under hypoxic conditions due to amino acid substitution on beta chain

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2
Q

What is glycoprotein IIb/IIIa a receptor for in platelet activation?

A

fibrinogen

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3
Q

How does cisplatin work?

A

cross-linking DNA

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4
Q

A pt with hereditary spherocytosis is likely to get what as a result?

A

pigmented gallstones

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5
Q

What are the leukocytes in hairy cell leukemia stained with?

A

tartrate-resistant acid phosphatase

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6
Q

Which measurements are affected by tPA?

A

PT and PTT bc it degrades fibrin and fibrinogen ( both pathways)

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7
Q

What is the microscopic hallmark of Burkitt Lymphoma?

A

Starry sky (lymphos interspersed w macros)

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8
Q

What are the genetic associations for Burkitt Lymphoma?

A

c-myc

t(8,14) translocation

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9
Q

In which 3 diseases is erythrocyte sedimentation rate decreased?

A

polycythemia
CHF
sickle-cell anemia

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10
Q

Which antibiotic decreases the metabolism of warfarin?

A

ketoconazole

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11
Q

What is Bernard-Soulier syndrome?

A

Defect in platelet plug formation.

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12
Q

What (3) hallmarks will diagnose Bernard-Soulier syndrome?

A
  1. Large platelets. 
  2. GpIb Ž defect in platelet-to-vWF adhesion.
  3. Abnormal ristocetin cofactor assay.
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13
Q

Which clusters of differentiation (CD) identify Reed-Sternberg cells?

A

CD 30 and CD15

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14
Q

What differentiates polycythemia vera w reactive polycythemia vera?

A

reactive = cases of tissue hypoxia (smokers, decreased O2 saturation)

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15
Q

Which translocation is associated with Acute Promyelocytic Leukemia?

A

t(15;17)

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16
Q

How does aspirin induce antiplatelet effects?

A

inhibits COX –> inhibits thromboxane A2 (platelets cant aggregate)

17
Q

Granules in eosinophils will contain which protein?

A

Major basic protein

18
Q

Which class of antibiotics can potentiate wrfarin’s effects and cause bleeding?

A

macrolides (-mycin)

19
Q

How does streptokinase cause thrombolysis?

A

Binding to plasminogen = release plasmin

20
Q

Whats the MOA of ticlopidine?

A

Inhibits platelet aggregation by preventing adenosine diphosphate from binding to platelet receptors

21
Q

What is Porphyria cutanea tarda?

A

Uroporphyrinogen decarboxylase (UROD) deficiency (5th setp in heme synthesis pathway)

22
Q

What are clinical manifestations of Uroporphyrinogen decarboxylase (UROD) def?

A
  1. tea-colored urine
  2. Blistering cutaneous photosensitivity

(Most common porphyria)

USMLE Step 1 (13 decks)

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