hematology immunology Flashcards
Malaria gets how many slides
1 thic and 1 thin
Hemaglobin
provides a direct indication of the oxygen transport capcity of the body
hematocrit
the percentage volume of blood that is composed of RBCs
CBC RBC indices
access RBC characrerisitics and are useful for/in the evaluation of anemias cancer and disorders
MCV
mean cell volume most useful RBC indiced RR 80-96 fL
MCH
Mean Cell Hemoglobin - the average weight of hemoglobin in rbc RR 27-33pg
MCHC
Mean Cell Hemoglobin Concentrion the average amount of hemoglobin per volume of RBC
RDW
Red BLood DIstribution Width an indication of the variation of Red Cell Size (anisocytosis) RR 11.5-14.5%
QA and QC
quailty assurance and quailty control
Hemataposiesis
formation of new blood cells
Erythropoiesis
formation of RBC stimulated by erythropoietin
Anemia
reduction in red blood cells or ditruction of hemoglobin
WBC come from
lymphoid progenitor cells and myeloid progenitor cells
where are platelets produced
bone marrow
Hemostasis cascade steps
Constriction of the blood vessel.
Formation of a temporary “platelet plug.”
Activation of the coagulation cascade. 4) Formation of “fibrin plug” or the final clot.
Intrinsic Pathway
stimulated by endothelium damage
Extrinis pathway
stimulated by external injury to blood vessels
what is the final common pathway
factor 10 - leads to conversion of prothrombin to thrombin and thrombin converts fibrinogen into the fibrin mesh
Arteries carry blood in what direction
away from the heart
veins carry blood in what direction
towards the heart
6 stages of development of an RBC
Rubriblast
Prorubricyte
Rubicyte
Metarubricytes
Reticulocyte
Mature Erythrocyte
Reference range RBC
m 4.5-5.9 x10^12/L
f 4.5-5.1 x 10^12/L
Hematocrit reference ranges
m 41.5-50.4%
f 35.9-44.6%
Hb Reference range
14.17.5 g/dL
12.3-15.3 g/dL
platelet reference range
150-450 x10^12/L
in circulating blood how many rbcs are normally reticulocytes
0.5-2.5% adults and 2.5-6.0 babys