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Pedia > Hematology > Flashcards

Hematology Flashcards

1
Q

RBC production
Neurologic function
DNA synthesis

A

Vit B12 cyanocobalamin

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2
Q

inadequate intake, stomach or ileal surgery

lack of intrinsic factor secretion (pernicious anemia)

A

B12 deficiency

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3
Q

B12 deficiency causes excessive in urine

A

methylmalonic acid

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4
Q

Test for B12 absorption

A

Schilling test

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5
Q

transport form of cobalamin

A

transcobalamin

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6
Q

rf for b12 deficiency

A

dec ileal absorption
crohn’s disease
ileal resection
d latum infection

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7
Q

Dec intrinsic factors

A

Atrophic gastritis
Pernicious anemia
Postgastrectomy syndrome Roux en Y
Genetic

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8
Q

Most common hematologic disease of infancy and childhood

1mg iron absorbed daily

Exclusively breastfed infants must be supplemented by

A

IDA

4 mos

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9
Q

Hereditary spherocytosis deficiency

A

Spectrin
Ankyrin
Band 3 or protein 4.2

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10
Q

Most common familial congenital abnormality of RBC membrane

A

Hereditary spherocytosis

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11
Q

Dx spherocytosis

A

Osmotic fragility test

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12
Q

Most common congenital coagulation disorder

A

Hemophilia

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13
Q 
X linked
Factor 8
Ms joint surgical sites
Normal PT
Prolonged PTT
A

Hemophilia A

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14
Q

Hemophilia B

A

Factor 9 deficiency

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15
Q

Hemophilia A
Hemarthrosis
Inc PTT
Normal BT PT

A

Factor 8 deficiency

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16
Q

Hemophilia B

Christmas disease

A

Factor 9 deficiency

17
Q

Vascular hemophilia
Most common hereditary bleeding disorder
Prolonged BT PT

A

Von Willebrand

18
Q

Vit K deficiency
Factors 1972
More common in breastfed infant due to lack of free Vit K
Absence of bacteria responsible for Vit K synthesis in intestine

Labs: prolonged PT, PTT
Tx: Vit K

A

Hemorrhagic disease in newborn

19
Q

Most common leukemia in children 85%

A

Acute Lymphoblastic Leukemia

20
Q

Leukemia peaks at age

A

4

21
Q

Boys > girls
Constitutional s/sx: bleeding, pallor, petechiae, splenomegaly, bone pain

Dx:

A

Acute lymphoblastic leukemia

Blast cells on PBS
low WBC
Lymphoblastic

22
Q

Rf in acute lymphoblastic

A 
Radiation
Drugs alkylating agent
Nitrosurea
Benzene
Advanced maternal age
DS
23
Q

Dx of ALL

A

bone marrow aspiration

24
Q

Predominant neonatal
congenital leukemia

Pain fever bleeding hepatosplenomegaly gingival hypertrophy

Down, Fanconi anemia, Diamond Blackfan anemia

A

AML

25
Q

AML Dx +

A

myeloperoxidase

26
Q

Philadelphia chromosome

A

translocation of 9:22 CML

BRL-ABC

27
Q

Burkitt lymphoma translocation

A

8:14

Myc:BHL

28
Q

Burkitt’s biopsy

A

Starry sky appearance

29
Q

Hodgkin cardinal histology

A

Reed sternberg cell

Hx type
Nodular sclerosing - most common
Mixed cellularity
Lymphocytic predominance
Lymphocytic depleted
30
Q

Owl eye appearance

Mirror image

A

Reed Sternberg

Hodgkin’s

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