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MLT Exam > Hematology > Flashcards

Hematology Flashcards

1
Q

The diffrenced between CML and a leukmoid reaction are

A

Leukmoid: INCREASED LAP, INCREASED toxic granulation, Dohle Bodies, and Ph chromosome negative

CML: DECREASED LAP, DECREASED toxic granulation, NO Dohle bodies, Ph chromosome positive

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2
Q

HCT NV

A

37-53%

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3
Q

RDW NV

A

11.5-14.5 %

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4
Q

Hemolysis and hemolytic anemia would cause Hgb A1c levels to

A

Decrease

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5
Q

MCH equation

A

HGB/RBC x 10

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6
Q

In POSThepatic jaundice (i.e. obstructive jaundice), describe the bilirubin results

A 
Serum unconjugated: Normal
Serum conjugated: INCREASED
Urine Bilirubin: INCREASED
Urine Urobiliogen: DECREASED
Marked increased in GGT, AST, ALT
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7
Q

MCHC NV

A

32-36 %

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8
Q

In Hepatic jaundice (i.e. cirrosis, viral hepatitis), describe the bilirubin results

A

Serum Unconjugated: INCREASED
Serum Conjugated: INCREASED
Urine Bilirubin: 0 or INCREASED
Urine Uronbilinogen: INCREASED

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9
Q

Nephrotic syndrom results from damage to the kidney. What will you find increased in the urine?

A

Albumin

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10
Q

WBC NV

A

4.8-10.8 x10^9

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11
Q

PLT NV

A

150-450 x10^9

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12
Q

What does creatinine clearance help estimate?

A

The glomular filtration rate (the rate of blood flow through the kidneys)

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13
Q

MCV NV

A

800-100 fL

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14
Q

Where are Heinze bodies found and what are they composed of?

A

Inner RBC membrane

Denatured hemoglobin

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15
Q

MCHC equation

A

HGB/HCT X 100

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16
Q

MCH NV

A

27-31 pg

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17
Q

HGB NV

A

M: 14-18
F: 12-16 g/dL

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18
Q

Characteristics of G6PD deficiency

A 
Causes hemolysic crisis
Jaundice (neonatal and adult)
Avoid Triggers
Malaria protection
HEINZ BODIES
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19
Q

RBC NV

A

4.2-6.1 x10^9

20
Q

Heinz bodys can be seen in

A

G6PD deficiency
Alpha thalassemia
drug induced hemolytic anemia
chronic liver disease

SUPRAVITAL STAIN

21
Q

Corrected RBC formula

A

(uncorrected WBC x100)/(nRBCS/100) + 100

22
Q

MCV equation

A

HCT/RBCs x 10

23
Q

Acute myelogenous leukemia: to many _____

Chronic myelogenous leukemia: to many _____

A

AML: blasts
CML: mature cells (mostly affects adults)

24
Q 
Normal Values
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
RDW
PLT
A 
WBC       4.8-10.8   x 10^9 L
RBC        4.2-6.1     x10^6 uL
HGB M   14-18        g/dL
HGB F    12-16        g/dL
HCT        37-52       %
MCV       80-100     fL
MCH       27-31        pg
MCHC    32-36       %
RDW       11.5-14.5   %
PLT         150-450    x10^9
25
Q

In Alpha Thalassemia (also known by its defective hemoglobin), these two unstable hemoglobins are present. Describe abnormal blood smear findings

A 
Hemoglobin Barts (tetrameric gamma chains)
Hemoglobin C (tetrameric beta chains)

Microcytic anemia, target cells, HEINZ bodies

26
Q

How is indirect (uncongugated) bilirubin converted into direct (congugated) bilirubin?

A

Uncongugated bilirubin is conjugated with two molecules of glucaronic acid (enzyme glucuronyl transferase)

27
Q

Napathalene poisoning is evident by seing this in a blood smear (suprvital)

A

Heinze bodies

28
Q

In PREhepatic jaundice (i.e. hemolytic anemia), describe the bilirubin results.

A

Serum Unconjugated: INCREASED
Serum Conjugated: Normal
Urine bilirubin: 0
Urine Urobilinogen: INCREASED

29
Q

Multiple Myeloma smear findings

A

Rouleux
NRBCs
Teardrop Cells

30
Q

The major iron storage compound is

31
Q

Iron Labs in Iron Deficiency

A

DECREASED serum ferritin
DECREASED serum Fe
INCREASED TIBC
DECREASED sautration

32
Q

Iron Labs in Chronic Disease/Inflammation

A

N-INCREASED serum ferritin
DECREASED serum Fe
DECREASED TIBC

33
Q

Iron Labs in Lead Poisoning

A

Basophilic Stippling
Increased Pb
Increased FEP

34
Q

Which hemoglobins migrates with A2

A

C
E
O arab
C harlem

A2 CE Of Clubes

35
Q

Which hemogbolins migrate with S

A

D
G
Lepore

Sad Dogs Get Loved

36
Q

A patients lymphocytes demonstrate cytoplasmic projects and a POSITIVE TARTRATE-RESISTANT acid phosphatase stain. What is the most likely diagnosis?

A

Hair Cell leukemia

37
Q

Bernard Soulier syndrome is characterized by

A

Increased bleeding time

Giant platelets

38
Q

Vitamin K dependent factors

39
Q

von Willebrands
# PLTs
PLT morphology
Assay”

A

PLTs: normal
PLT morpholgy: normal
Assay: abnormal adhesion, ristocetin decreased, vWF is absent

40
Q

What is commonly associated with CMML

A

lysozymuria

41
Q

In CML, blood histamine levels reflect

A

the amount of basophils present

42
Q

The Phillidelphia chromosome is most closely releated to

A

Chronic myelogenous leukemia

43
Q

All stages of neutrophils are likely to be seen in the peripheral blood in CML/AML

44
Q

1/3 of CML cases progress to

A

ALL

Acute lymphocytic leukemia

45
Q

Chronic lymphocytic leukemia is defined as

A

accumulation of monoclonal B cells with a block in maturation

MLT Exam (8 decks)

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