Clinical immunology Flashcards
Neutrophil:
Where are they found (in %) and there function.
Found: 50-75% of circulating WBC’s
Function: First responder to infection, phagocytosis
Eosinophil:
Where are they found (in %) and there function.
Found: 1-3% of circulating WBC’s
Function: kill parasites, neutralize basophil and mast cell production, regulate mast cells
Basophill:
Where are they found (in %) and there function.
Found: < 1% of circulating WBC’s
Function: Induce and maintain allergic reactions, stimulate production of IgE
Mast cell:
Where are they found (in %) and there function.
Found: Skin, connective tissue, mucosal epithelium
Function: Antigen presentation to T and B cells
Enhancement and suppression of the adaptive immune response
Monocyte:
Where are they found (in %) and there function.
Found: 4-10% of circulating WBC’s
Function: Phagocytosis, migrate to tissues to become macrophages
Macrophage:
Where are they found (in %) and there function.
Found: Lungs, brain, bone, connective tissue, other tissue
Function: Phagocytosis, kill intracellular parasites; tumoricidal activity; antigen presentation to T and B cells
Dendritic Cell:
Where are they found (in %) and there function.
Found: Skin, Mucous membranes, heart, lungs, liver, kidney, other tissue
Function: Most potent phagocytic cell; most effective at antigen presentation
Lymphocyte:
Where are they found (in %) and there function.
Found: 20-40% of circulating WBCs, also found in lymph nodes, spleen, other secondary lymphoid organs
Function: Subtypes are T cells, B cells, and NK cells, T Cells produce cytokines, B cells produce antibody in adaptive immune response, and NK cells are involved in Innate immunity
What are the Antigens in T Cells
CD2, CD3, CD4, CD8
What are the Antigens in B Cells
CD19, CD20, CD21 surface antibody
What are the antigens in NK Cells
CD16, CD56
Difference between Class I MHC Molecules and Class II MCH Molecules
With Cellular distribution
Class I: All nucleated Cells
Class II: B cells, Monocytes, Macrophages, Dendritic cells, Thymic epithelial cells
Difference between Class I MHC Molecules and Class II MCH Molecules
With Classes
Class I; A, B, C
Class II: DP, DQ, DR
Difference between Class I MHC Molecules and Class II MCH Molecules
With Interaction with T Cells
Class I: Presents endogenous antigen to CD8+ T Cells
Class II: Presents exogenous antigen to CD4+ T Cells
What are the diffrences between T Cells and B Cells in regard to
Where is it develop
Where is it found
What is it Identified by
End product activation
Antigens
Located
What are the Antibody’s Structures
What are the Five classes of antibodies?
IgM, IgG, IgA, IgD, and IgE
G.A.M.E.D
What are IgG characteristics
IgG Relatively small and easily penetrates tissues
What are IgA characteristics
IgA Has an SC that protexts it and enzymatic digestion whiles it patrols mucosal surfaces
What are IgE characteristics
IgE Binds to Mast cells to initiate a local inflammatory reaction
What are IgM characteristics
IgM is large and excels at complement fixation
How long dose it take for a primary antigen response and
what are the primary Antigen classes
5 to 7 days
Primary response is mostly equal amounts of AgM and IgG
What are the Major Cytokines involved in the initial stages of the inflammatory response
IL-1, IL-6, TNF-α and the chemokines
These cytokines are responsible for inflammation symptoms
NOTE: IL is Interleukin
What is important about Interleukin-6 (IL-6)
And what is it secreted by?
Secreted by Monocytes, Macrophages, Endothelial cells, Th2 cells
Initiation of the acute-phase response and activation of B and T Cells
