Clinical immunology Flashcards
Neutrophil:
Where are they found (in %) and there function.
Found: 50-75% of circulating WBC’s
Function: First responder to infection, phagocytosis
Eosinophil:
Where are they found (in %) and there function.
Found: 1-3% of circulating WBC’s
Function: kill parasites, neutralize basophil and mast cell production, regulate mast cells
Basophill:
Where are they found (in %) and there function.
Found: < 1% of circulating WBC’s
Function: Induce and maintain allergic reactions, stimulate production of IgE
Mast cell:
Where are they found (in %) and there function.
Found: Skin, connective tissue, mucosal epithelium
Function: Antigen presentation to T and B cells
Enhancement and suppression of the adaptive immune response
Monocyte:
Where are they found (in %) and there function.
Found: 4-10% of circulating WBC’s
Function: Phagocytosis, migrate to tissues to become macrophages
Macrophage:
Where are they found (in %) and there function.
Found: Lungs, brain, bone, connective tissue, other tissue
Function: Phagocytosis, kill intracellular parasites; tumoricidal activity; antigen presentation to T and B cells
Dendritic Cell:
Where are they found (in %) and there function.
Found: Skin, Mucous membranes, heart, lungs, liver, kidney, other tissue
Function: Most potent phagocytic cell; most effective at antigen presentation
Lymphocyte:
Where are they found (in %) and there function.
Found: 20-40% of circulating WBCs, also found in lymph nodes, spleen, other secondary lymphoid organs
Function: Subtypes are T cells, B cells, and NK cells, T Cells produce cytokines, B cells produce antibody in adaptive immune response, and NK cells are involved in Innate immunity
What are the Antigens in T Cells
CD2, CD3, CD4, CD8
What are the Antigens in B Cells
CD19, CD20, CD21 surface antibody
What are the antigens in NK Cells
CD16, CD56
Difference between Class I MHC Molecules and Class II MCH Molecules
With Cellular distribution
Class I: All nucleated Cells
Class II: B cells, Monocytes, Macrophages, Dendritic cells, Thymic epithelial cells
Difference between Class I MHC Molecules and Class II MCH Molecules
With Classes
Class I; A, B, C
Class II: DP, DQ, DR
Difference between Class I MHC Molecules and Class II MCH Molecules
With Interaction with T Cells
Class I: Presents endogenous antigen to CD8+ T Cells
Class II: Presents exogenous antigen to CD4+ T Cells
What are the diffrences between T Cells and B Cells in regard to
Where is it develop
Where is it found
What is it Identified by
End product activation
Antigens
Located
What are the Antibody’s Structures
