Hematology

Question 1

Deficiency of what factor may predispose a person to recurrent thrombosis?

Answer 1

Protein C Deficiency

Question 2

What factor is deficient in Hemophilia B?

Answer 2

Factor IX

Question 3

The treatment for Hemophilia A are Factor VIII transfusions. For an acute episode what can also be used?

What genetic pattern is Hemophilia A?

Answer 3

Desmopressin

X-linked Recessive (boys more impacted)

Question 4

True or false: factor V Leiden is a bleeding disease.

Answer 4

False. Factor V Leiden is an inherited clotting disease, or thrombophilia. Misshapen factor V proteins cause excessive clotting.

Question 5

What blood cell changes are seen in labs associated with alpha thalassemia?

Answer 5

Microcytosis, hemolytic anemia (schistocytes, tear drop cells, increased reticulocytes), target cells, increased RBC count, decreased hemoglobin

+ Heintz Bodies

Question 6

What is the most common hereditary bleeding disorder and what is the genetic inheritance pattern?

Answer 6

Von Willebrand Disease, is an autosomal dominant disorder associated with ineffective platelet adhession due to deficiency in Von Willebrand Factor

Question 7

What is the first line treatment for Von Willebrand Disease?

Answer 7

Desmopressin