Hematology

Question 1

Sickle cell patient pre op transfusion goal

Answer 1

Preoperative simple transfusion should be performed, targeting a hemoglobin level of 10 g/dL (100 g/L)

Question 2

How does hydroxyurea work in sickle cell

Answer 2

Its efficacy appears to be partially related to increasing hemoglobin F production and decreasing the relative concentration of hemoglobin S.

Question 3

When to use hydroxyurea in SS patients?

Answer 3

It should be considered for use in adults who have significant clinical manifestations, including three or more painful vaso-occlusive events per year.