Hematology Flashcards
Connective tissue composed of cells suspended within a liquid intercellular matrix
Blood
Liquid Intracellular matrix withing which blood is suspended
Plasma
Blood color for oxygenated _____ , and low oxygen _____
Bright red, dark blueish red
Quantity of blood in an average person
5 liters
Viscosity of Blood
3 to 4 times thicker than water
Blood composition, percentage ____% plasma, and
____% formed elements
52-58%, 42 -48%
Measurement of the percent formed elements in the blood
Formed elements components, ____, _____, and _____
Red blood cells (Corpuscles), White blood cells (Leukotocytes) and, Platelets (Thrombocytes)
Red Corpuscles
Red blood cells
Leukotocytes
White Blood cells
Thrombocytes
Platelets
Blood pH
slightly alkaline around [ 7.4 ]
Vital molecule found in erythrocytes, consisting of globular protein portion (globin) and four heme groups
hemoglobin
Oxygenated Hemoglobin
Oxyhemoglobin
Hemoglobin w/o oxygen
Reduced Hemoglobin
Hemoglobin with carbon dioxide bound to it
Carbaminohemoglobin
In red marrow, this is the precursor cell for all blood cells
hemocytoblast
In red blood cells the HEMOCYTOBLAST develops into this rapidly dividing cell
erythroblast
Red cells released from the bone marrow
reticulocytes
(the presence of these in the blood indicates active bone marrow)
There are _____ million erythrocytes per cubic mm. of blood
4.5 to 5.5
of the 75 trillion cells in the human body 25 trillion are _____
erythrocytes
Two vitamins required for DNA synthesis in diving cells are _____ and _____
Vitamin B and Folic Acid
Type of factor the stomach lining contains, that promotes the absorption of vitamin B12
Intrinsic
This hormone, that is produced by the liver and kidneys, stimulates erythrocyte production
erythropoietin
A type of Erythrocyte abnormality, a REDUCED HEMATOCRIT with a decrease in red cell count
Anemia
Inadequate dietary Iron intake causes this
Iron deficiency anemia
This is caused by red marrow failure as can occur in radiation exposure
Aplastic anemia
This is caused by substitution of improper amino acids in the hemoglobin molecules
Sickle Cell Anemia
This is an increase in Hematocrit with the concentration of red blood cells above normal
Polycythemia
Three types of Granular Leukocytes, ______,
______, and _______
Neutrophils, Eosinophils, Basophils
These Granular Leukocytes make up 60% of the total number of white cells, they are micro-phagocytes
Neutrophils
These Granular Leukocytes compose less than 3% of the total number of white cells, ACIDIC STAINS, and involved with detoxification of foreign proteins entering the lungs and digestive system
Eosinophils
These Granular Leukocytes make up less than 1% of white cells, act by releasing heparin and histamine at the site of damaged tissue
Basophils
This is a vasoactive agent that increases blood flow to the affected area, and allows the space to fill with fluid
Histamine
This prevents the formation of blood clots helping them to maintain continuous blood flow to damaged tissue
Heparin
Two types of Agranular Leukocytes _____, and _____
Lymphocytes, and Monocytes
This type of agranular leukocyte composes about 30% of white cells, are the key players in specific immunological defense (immune) system
Lymphocytes
This type of agranular leukocytes are the largest of the white cells, making up about 5% of the white cell count, act as macrophagocytes digesting large amounts of debris with lysosomal enzymes
Monocytes
There are usually ____to _____ thousand leukocytes per cubic mm of blood
5-10
Neutrophils, Eosinophils, Basophils, and monocytes are examples of this _______ response
inflammatory
Decrease in the number of circulating white cells
Leucopenia
Increase in the white blood cell count
Leukocytosis
Cancer of the leukocytes
Leukemia
Cancer of the leukocytes, which were derived from the bone marrow
Myeloid Lukemia
Cancer of the leukocytes, which are associated with the lymph nodes
Lymphoid Leukemia
with leukemia the patients resistance to infection is _____ due to the cells being both anatomically and functionally abnormal
Decreased
This refers to the prevention of blood loss
Hemostasis
Platelets, important for plugging the hundreds of small ruptures that occur throughout the vasculature each day
Thrombocytes
Thrombocytes are fragments of these LARGE cells that like other blood cells are derived from hemocytoblasts in red bone marrow
Megakaryocytes
There are around ____ to _____ thousand platelets per cubic mm. of blood
150 to 350
At the site of a rupture platelets will act as plugs and release this vasoconstrictor that reduces blood flow in a damaged vessel
Serotonin
The synthesis of prothrombin in the liver requires this vitamin
Vitamin K
This factor produced by the liver, circulates in inactive form in the plasma
Fibrinogen
Damaged vessels release this kind of substance that causes prothrombin to be converted to thrombin (active form)
Activator
This active form of prothrombin
Thrombin
These ions are necessary for the activation of prothrombin to thrombin
Calcium
The activation of prothrombin leads to the conversion of fibrinogen to this,
Fibrin
these proteins form long strands that intertwine making a meshwork over a ruptured area, ultimately pulling the ends of the rupture together
Fibrin
This is a type of clotting abnormality, is a genetic disease characterized by lack of one of the clotting factors
they don’t bleed more, but they bleed longer which lead to more blood loss
hemophilia
A stationary clot that actually plugs the vessel itself is called this
Thrombus
A wandering clot, one that has become dislodged from the vessel wall is called this
Embolus
Plasma is made up of 92% what
water
Water, salts, hormones, gases, nutrients, waste products and liver proteins make up
Plasma
The three types of liver proteins that make up part of plasma are _____, ______, and _______
Albumin, Globulins, and Clotting factors
This liver protein aids in maintaining colloidal osmotic pressure, also acts as a CARRIER for certain other blood borne groups
Albumin
This liver protein transports certain fat molecules and vitamins in the blood,
Globulins
A class of globulins that is produced by lymphocytes and act as antibodies
Gamma Globulins
This kind of liver protein, including prothrombin and fibrinogen, prevents blood loss and aids in hemostasis
Clotting Factors
The most familiar blood group
ABO group
Universal donor blood group
Type O
Universal recipient blood group
Type AB
Blood group first discovered in rhesus monkeys
Rh group
what percent of the human population is Rh +
85%
The first line of defense against harmful pathogens
external barriers of the body, skin, mucous membranes
The second line of defense against harmful pathogens
internal physiological mechanisms, phagocytosis, inflammation and fever
The third line of defense against harmful pathogens is
The immune system (Recognize, react, remember)
The part of the antigen that serves as the recognition factor
epitope
This is released by a T helper cell, and stimulates the programmed B cell to divide repeatedly forming clones
Interleukin