Hematologic Malignancies Flashcards
CML
Chronic Myelogenous Leukemia
Cancer of white blood cells
Unregulated growth of myeloid cells
Which chromosomal translocaiton is associated with CML?
Philadelphia Chromosome
CML patho
Bcr-Abl gene mutation
CML phases
Chronic phase (5-6 yrs) Accelerated phase (6-9 mo) Blast crisis (3-6 months until death)
CML peripheral smear
Increased myeloid cells
Increased bands
NOT increased blasts
Gleevec
Imatinib Mesylate
Decreases risk of blast crisis in CML
Plasmacytoma
Solitary Malignant plasma cell tumor
Often progresses to MM within 2-4 years
Multiple Myeloma (MM)
Cancer of the plasma cells
Cancer of the elderly (70)
High incidence in african americans and pacific islanders.
MM S/S
Bone lesions Bone pain Anemia Fatigue Elevated creatinine Hypercalcemia
M protein
Monoclonal protein
Found in Multiple Myeloma
Roleaux formation =?
MM
Chronic Lymphocytic Leukemia (CLL)
Most common leukemia in adults
Affects B-cell lymphocytes
Affects older women > men (2:1)
CLL S/S
Most are asymptomatic Fatigue Infection Organomegaly Lymphadenopathy Leukemia cutis
CLL blood findings
Lymphocytopenia
Smudge cells
Normal Hct, platelets
Allogenic
From another person
Syngenic
From identical twin
Autologous
From self
Polycythemia Vera (PV)
Clonal stem cell disorder characterized by increased red cell production.
PV epidemiology
55-60 years
Males > Females
PV S/S
Thrombosis DVT HTN HA, dizziness Hepatosplenomegaly Redness, heat Elevated H/H
What happens after a shower in PV?
Prutitis
PV tx
Hydroxyurea
Low dose ASA
