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Oncology :( > Day One > Flashcards

Day One Flashcards

1
Q

Phase I

A

15-30 ppl
Route and dose determination
Safety issues

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2
Q

Phase II

A

Less than 100 ppl

Is the tx effective?

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3
Q

Phase III

A

from 100 to thousands of ppl.
How does tx compare to current standard?
How does it compare to placebo

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4
Q

Phase IV

A

Takes place after drug is approved.

Provides additional info

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5
Q

Most common cancer in women?

A

Breast

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6
Q

Most common cancer in men?

A

Prostate

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7
Q

G1

A

RNA, Protein synthesis, cell growth

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8
Q

S phase

A

DNA synthesis

Produces 2 sets of chromosomes

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9
Q

G2

A

RNA, protein synthesis, cell growth

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10
Q

M Phase

A

Mitosis, division

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11
Q

G0

A

Resting phase

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12
Q

Cyclins and CDK

A

Together are needed to push cells through each phase of the cycle

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13
Q

CDK inhibitors

A

Gatekeepers for checkpoints

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14
Q

Checkpoint btw G1 and S phase checks for?

A

Checks for DNA damage

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15
Q

Checkpoint between G2 and M phase checks for?

A

Damaged or unduplicated DNA.

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16
Q

Benign

A

Noncancerous tumors

Well differentiated cells that resemble surrounding tissue.

17
Q

Malignant

A

Grow rapidly, invade and destroy nearby tissue.
Poorly differentiated cells
More cells seen in mitosis

18
Q

Adenoma

A

Benign tumor of glandular epithelial tissue.

19
Q

Osteoma

A

Benign tumor of the bone

20
Q

Carcinoma

A

Malignant tumor from epithelial tissue organ.

Further specified to tissue type

21
Q

Sarcoma

A

Malignant tumor of mesenchymal origin.

22
Q

Papilloma

A

Benign, contains finger-like projections and grow on any surface.

23
Q

Anaplasia

A

Loss of cell differentiation in cancerous tissue.

24
Q

Pleomorphic

A

Cells and nuclei are variable in size and shape

25
Q

Carcinoma in situ

A

Localized
Cells have not crossed basement membrane
Usually have good cure rates and prognosis.

26
Q

Do cancer cells have to be anchored to survive?

A

No

27
Q

Cancer cell life span?

A

Infinite, can divide unlimited amount of times

28
Q

Seeding

A

Occurs when a tumor sheds cells into body cavities and causes fluid accumulation.

29
Q

Four viruses associated with cancer?

A

HPV
EBV
HBV
HHV-8

30
Q

T1 scan

A

Water dark, fat bright

31
Q

T2 Scan

A

Water bright, fat dark

32
Q

SPECT scan good for?

A

Small spine lesions

33
Q

Which contrast agent used for MRI?

A

Gadolinium

Helps delineate surrounding vascularity

34
Q

Fludeoxyglucose (FDG)

A

Contrast used for PET

Oncology :( (9 decks)

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