Day One

Question 1

Phase I

Answer 1

15-30 ppl
Route and dose determination
Safety issues

Question 2

Phase II

Answer 2

Less than 100 ppl

Is the tx effective?

Question 3

Phase III

Answer 3

from 100 to thousands of ppl.
How does tx compare to current standard?
How does it compare to placebo

Question 4

Phase IV

Answer 4

Takes place after drug is approved.

Provides additional info

Question 5

Most common cancer in women?

Answer 5

Breast

Question 6

Most common cancer in men?

Answer 6

Prostate

Question 7

G1

Answer 7

RNA, Protein synthesis, cell growth

Question 8

S phase

Answer 8

DNA synthesis

Produces 2 sets of chromosomes

Question 9

G2

Answer 9

RNA, protein synthesis, cell growth

Question 10

M Phase

Answer 10

Mitosis, division

Question 11

G0

Answer 11

Resting phase

Question 12

Cyclins and CDK

Answer 12

Together are needed to push cells through each phase of the cycle

Question 13

CDK inhibitors

Answer 13

Gatekeepers for checkpoints

Question 14

Checkpoint btw G1 and S phase checks for?

Answer 14

Checks for DNA damage

Question 15

Checkpoint between G2 and M phase checks for?

Answer 15

Damaged or unduplicated DNA.

Question 16

Benign

Answer 16

Noncancerous tumors

Well differentiated cells that resemble surrounding tissue.

Question 17

Malignant

Answer 17

Grow rapidly, invade and destroy nearby tissue.
Poorly differentiated cells
More cells seen in mitosis

Question 18

Adenoma

Answer 18

Benign tumor of glandular epithelial tissue.

Question 19

Osteoma

Answer 19

Benign tumor of the bone

Question 20

Carcinoma

Answer 20

Malignant tumor from epithelial tissue organ.

Further specified to tissue type

Question 21

Sarcoma

Answer 21

Malignant tumor of mesenchymal origin.

Question 22

Papilloma

Answer 22

Benign, contains finger-like projections and grow on any surface.

Question 23

Anaplasia

Answer 23

Loss of cell differentiation in cancerous tissue.

Question 24

Pleomorphic

Answer 24

Cells and nuclei are variable in size and shape

Question 25

Carcinoma in situ

Answer 25

Localized
Cells have not crossed basement membrane
Usually have good cure rates and prognosis.

Question 26

Do cancer cells have to be anchored to survive?

Answer 26

No

Question 27

Cancer cell life span?

Answer 27

Infinite, can divide unlimited amount of times

Question 28

Seeding

Answer 28

Occurs when a tumor sheds cells into body cavities and causes fluid accumulation.

Question 29

Four viruses associated with cancer?

Answer 29

HPV
EBV
HBV
HHV-8

Question 30

T1 scan

Answer 30

Water dark, fat bright

Question 31

T2 Scan

Answer 31

Water bright, fat dark

Question 32

SPECT scan good for?

Answer 32

Small spine lesions

Question 33

Which contrast agent used for MRI?

Answer 33

Gadolinium

Helps delineate surrounding vascularity

Question 34

Fludeoxyglucose (FDG)

Answer 34

Contrast used for PET