Breast Cancer Flashcards
1 in __ women will get breast cancer.
1 in 8
BRCA1 Carriers
Breast CA risk: 60%
Ovarian CA risk: 59%
Contralateral CA risk: 83%
BRCA2 Carriers
Breast CA risk: 55%
Ovarian CA risk: 16.5%
Contralateral breast CA risk: 62%
Breast Cancer risks
Births >30 yo
Tall stature
Family hx
Hormone exposure
Annual mammogram age?
Discuss starting at age 40
annual from 40 - 74
Which views are taken in the mammogram?
Craniocaudal
Mediolateral oblique
Stage 1
Tumor <2cm
No nodes
Stage 2
Positive, but ipsilateral and mobile nodes
OR
Tumor size >2cm
Stage 3
Extensive axillary nodal dz.
Supraclavicular node involvement
Stage 4
Metastatic dz
Non-invasive Breast CA
Ductal carcinoma in-situ.
Confined to breast ducts and lobules
Invasive Breast CA
Tumor cells that invade breast stroma
Most common type of breast CA
DCIS
Ductal carcinoma in-situ
Affects one breast
20% of all breast CA
LCIS
Lobular Carcinoma In-Situ
Never a palpable lesion
Incidental microscopic finding
Biopsy
Types of invasive breast CA
Infiltrating ductal carcinoma: 70-80%
Lobular invasive carcinoma: 5-10%
Ductal/lobular: 7%
Colloid/tubular/medullary/papillary: 6%
Paget’s Dz
Disorder of nipple and areola.
Crusting, scaling, erosion
ALways associated w/ underlying mammary CA
Inflammatory Breast CA
Rapidly progressive tumor w/ high chance for early mets.
Pain, tender, firm enlarged breast, warm skin
Tamoxifen
Therapy used for ER/PR positive tumors
Aromatase inhibitors
Used for postmenopausal women.
Trastuzumab
Used for overexpression of HER2.
HER2
Human epidermal growth factor receptor 2.
Which chemo agent causes renal injury?
Cysplatin
Which chemo agent causes cardiac complications?
Doxyrubicin
Which chemo agent causes pulmonary fibrosis?
Bleomycin
Tamoxifen causes?
Blood clots
