Breast Cancer

Question 1

1 in __ women will get breast cancer.

Answer 1

1 in 8

Question 2

BRCA1 Carriers

Answer 2

Breast CA risk: 60%
Ovarian CA risk: 59%
Contralateral CA risk: 83%

Question 3

BRCA2 Carriers

Answer 3

Breast CA risk: 55%
Ovarian CA risk: 16.5%
Contralateral breast CA risk: 62%

Question 4

Breast Cancer risks

Answer 4

Births >30 yo
Tall stature
Family hx
Hormone exposure

Question 5

Annual mammogram age?

Answer 5

Discuss starting at age 40

annual from 40 - 74

Question 6

Which views are taken in the mammogram?

Answer 6

Craniocaudal

Mediolateral oblique

Question 7

Stage 1

Answer 7

Tumor <2cm

No nodes

Question 8

Stage 2

Answer 8

Positive, but ipsilateral and mobile nodes
OR
Tumor size >2cm

Question 9

Stage 3

Answer 9

Extensive axillary nodal dz.

Supraclavicular node involvement

Question 10

Stage 4

Answer 10

Metastatic dz

Question 11

Non-invasive Breast CA

Answer 11

Ductal carcinoma in-situ.

Confined to breast ducts and lobules

Question 12

Invasive Breast CA

Answer 12

Tumor cells that invade breast stroma

Most common type of breast CA

Question 13

DCIS

Answer 13

Ductal carcinoma in-situ
Affects one breast
20% of all breast CA

Question 14

LCIS

Answer 14

Lobular Carcinoma In-Situ
Never a palpable lesion
Incidental microscopic finding
Biopsy

Question 15

Types of invasive breast CA

Answer 15

Infiltrating ductal carcinoma: 70-80%
Lobular invasive carcinoma: 5-10%
Ductal/lobular: 7%
Colloid/tubular/medullary/papillary: 6%

Question 16

Paget’s Dz

Answer 16

Disorder of nipple and areola.
Crusting, scaling, erosion
ALways associated w/ underlying mammary CA

Question 17

Inflammatory Breast CA

Answer 17

Rapidly progressive tumor w/ high chance for early mets.

Pain, tender, firm enlarged breast, warm skin

Question 18

Tamoxifen

Answer 18

Therapy used for ER/PR positive tumors

Question 19

Aromatase inhibitors

Answer 19

Used for postmenopausal women.

Question 20

Trastuzumab

Answer 20

Used for overexpression of HER2.

Question 21

HER2

Answer 21

Human epidermal growth factor receptor 2.

Question 22

Which chemo agent causes renal injury?

Answer 22

Cysplatin

Question 23

Which chemo agent causes cardiac complications?

Answer 23

Doxyrubicin

Question 24

Which chemo agent causes pulmonary fibrosis?

Answer 24

Bleomycin

Question 25

Tamoxifen causes?

Answer 25

Blood clots