Hematologic Malignancies Flashcards
What is the only curative therapy for Myelodysplastic Syndrome?
Allogenic bone marrow stem cell Transplantation
How is Extreme Hyperleukocytosis treated?
Emergent Leukapheresis with Myelosuppressive Therapy
What is the treatment of choice for Chronic-phase Chronic Myeloid Leukemia?
Tyrosine Kinase Inhibitor
(Imatinib)
How is the Advanced Stage Disease of Chronic Myeloid Leukemia treated?
Tyrosine Kinase Inhibitor or Myelosuppressive Therapy
(Consider Stem Cell Transplant)
What is the Standard of Care for Early Indolent Chronic Lymphocytic Leukemia?
Observation
What are some indications for treatment in a patient with Chronic Lymphocytic Leukemia?
Progressive Fatigue
Symptomatic Lymphadenopathy
Anemia
Thrombocytopenia
What is the initial treatment for Chronic Lymphocytic Leukemia?
Target Biologic Therapy
(BTK inhibitor)
What is the treatment for a patient with Acute Myeloid Leukemia when you have a curative intent?
Cytarabine + Daunorubicin or Idarubicin
What is the treatment for a patient with Acute Lymphoblastic Leukemia?
Daunorubicin
Asparaginase
Vincristine
Prednisone
What is the treatment for Diffuse large B-Cell Lymphoma (Non-Hodgkins)
R-CHOP
(six cycles of immunochemotherapy)
What is the treatment of choice for a Low-risk patient with Hodgkin Lymphoma?
ABVD
(short course chemotherapy with nodal radiotherapy)
What is the treatment of choice for a High-risk patient with Hodgkin Lymphoma?
ABVD
(full course of chemotherapy for six cycles)
