Hemato oncology Flashcards
Hyperglycemia and skin findings(2)
glucagonoma
hemochromatosis
Skin findings in glucagonoma
NME necrolytic migratory erythema
Zone bastion de NME(3)
Face
extremities
perineum
Neurologic Manif of glucagonoma(3)
Demencia
ataxia
Proximal mx weakness
Confirmatory test of glucagonoma
Glucagon > 500pg/ml
Why anemia in glucagonoma(2)
Anemia of chronic disease
Glucagon directly affects erythropoiesis
Malt Lymphoma management(3)
Omeprazole
clarythro
Amox
Failure of antibio in Malt Lymphoma what to do?
CHOP + bleomycine
Quid for CHOP(4)
Cyclophosphamide
adryamycine
vincristine
Prednisone
classification of hyper ca++
Mild 10-12
Moderate 12-14
severe >14
Management of asymptomatic Mild Hyperca++
No rx needed
What to avoid in Mild hypercalcemia(4)
Hctz
Lithium
prolonged bed rest
volume depletion
rx of severe hyperca++(2)
Normal saline plus calcitonin
Biphosphonate
what’s the long term rx for hyper ca++
Biphosphonate
When to rx moderate hypercalcemia(2)
if symptomatic
rx similar to severe hyper ca++
Quid of Hairy celle leukemia
B cell tumor
Marker for Hairy cell leukemia
TRAP(Tartrate resistant acid phosphatase)
Rx of hairy cell leukemia
cladribine
What’s cladribine
Purine analog
clue for waldenstrom macroglobulinemia(3)
invasion of reticuloendothelial system
Sensory deficit
visual problems
quid for Waldenstrom
plasma cell proliferation
What’s the only blood cells to be normal or elevated in Waldenstrom
WBC
What explains the sensory deficit in Waldenstrom
demyelinating sensorimotor neuropathy
Physiopatho of Hyperviscosity in waldenstrom
excess of production of IGM
Disease causing gamma gap (4)
Amyloidosis
Multiple Myeloma
MGUS
waldenstrom
next step in in presence of isolated trombocytopenia
Test for HIV
What are the 2 main causes ot low platelet
Decrease production
Peripheral destruction
What virus could decrease platelet production(3)
HIV
epstein Barr
Hep C
What chemicals could cause decrease platelet production?(2)
Chemotherapy
Alcohol use
Congenital disease causing decreased platelet production
Fanconi syndrome
What carence could cause decreased platelet production(2)
B12
folate
What other disease can cause decreased platelet production
Myelodysplasia
Disease causing increased platelet destruction
Lupus antiphospholipid syndrome Idiopathic thrombocytopenic purpura TTP-HUS DIC
Drugs causing increased platelet destruction
Heparin
Non tender nodes in neck in older patient and smoker?
Squamous cell carcinoma of Head matastasis
Management of antiphospholipid syndrome in pregnant women
Low molecular weight Heparin
workup of antiphospholipid syndrome
prolonged PTT
thrombocytopenia
VDRL false positive
causes of anemia
RBC destruction
decrease red blood cell production
blood loss
cause of anemia in lymphoproliferative disorder
invasion of moelle osseuse
Cause of decreased red blood cell production(2)
Carence
Moelle osseuse problem
Physio patho of senile purpura
perivascular connective tissue atrophy
findings in senile purpura
dark ecchimosis in elderly
in area of trauma
People at risk for B12 anemia
Vegetarians
Symptoms of B12 anemia(2)
Memory loss
Balance problem
Megaloblastic anemia in alcoholic
B9 deficiency
if you give b9 to correct the megalobalstic anemia in a Veg what will happen?(2)
No more anemia
persistence of neurologic symtoms
Quid of polycythemia vera
erythropietin independent red blood cells overproduction
Hmg in polycythemia vera
Everything is high
why pruritus after bath in polycyhemia vera(2)
release of Histamine
and Prostaglandine
What causes release of histamine in Polycythemia vera
Mast cell degranulation
what cause release of prostaglandine
stimuli comming from red blood cells
How to explain the HTA
because of increase blood volume
How to explain face plethora in polycythemia vera
because of vasodilation(Histamine and prostaglandine)
Confirmatory test of polycythemia vera(2)
Low erythropoietin
JAK2V617F Mutation
Digestive problem in Polycthemia vera
Peptic ulceration
How to explain peptic ulceration in Polycythemia vera
Massive release of histamine
why abortion in antiphospholipid syndrome
because of thrombosis
arterial and veinous
why anemia in paroxystic nocturnal hemoglobinuria
hemolysis
what will be low in intra vxar hemolytic anemia(2)
Hb
Haptoglobin
What will be high in intra vxar hemolytic anemia
Bilirubin
LDH
why hemolytic anmemia in PNH
Absence of CD55 CD59 on RBC
Attack by complement
clue for PNH
Hepatic vein thrombosis
confirmatory DX for PNH(2)
Flow cytometry
Absence CD55 CD59
What explain absence of CD55 and 59 in PNH
GP1 abnormality
role of GP1
Help CD55 and CD59 to bind to RBC surface
Confirmatory test of Myastenia Gravis MG(2)
antibody to acethylcholine receptor
Electromyogram
If you confirm MG what will be the next step
Ct scan of chest for Thymoma
lung cancer in non smoker and smoker
adenocarcinoma
lung cancer with central localisation(2)S
Scc small cell carcinoma
SCC squamous cell carcinoma
Lung cancer with peripheral localisation(2)
adenocarcinoma
Large cell carcinoma
Paraneoplastic syndrome in Small cell carcinoma(3)
SiADH
Cushing syndrome
Lambert eaton syndrome
Paraneoplastic syndrome in squamous cell carcinoma
hypercalcemia
Paraneoplastic syndrome in Large cell carcinoma(2)
galactorrhea
gynecomastia
Paraneoplastic syndrome in adenocarcinoma(2)
clubbing
hypertrophic osteoarthropathy
Antibody produced in waldenstrom
IGM
Antibody mostly produced in MM
IGG
What cells are incriminated in MM
Plasma cells
Why reccurrent infection in MM
Inability to produce effective antibody
leukopenia
Clue for MM(CRAB)
High Calcium
ranal impairement
anemia
bone pain
What gamma gap
Protein total-albumin>3 a 4
Why renal impairement
IGG or paraprotein produced by myeloma cells collect in glomeruli and cause renal impairement
Why leukopenia and anemia in MM
Malignant cells invade moelles osseuse
Bone pain in MM
bone invasion and Lysis
Hypercalcemia in MM why?
Because of bone invasion
management of prostate cancer with metastasis
orchiectomy
Despite of orchiectomy pain persist in prostate cancer what ‘s the next step?
radiation
why orchiectomy in advanced prostatic cancer?
because androgen plays a key role prostactic cancer
workup for Hemachromatosis(3)
serum iron
HFE gene marker
Liver biopsy
What are the six organs targeted by hemochromatosis
Liver Pancreas Heart Pituitary gland skin Musculoskeletic system
quid of cardiac problem(3) in hemochromatosis
restrictive cardiomyopathy
dilated cardio
trouble de conduction
Quid of pancreas problem in hemochromatosis
Diabetes
Skin problem in hemochromatosis
Hyperpigmentation of skin
Pituitary problem in Hemochromatosis
Hypoptuitarism
quid Hypopituitarism(2)
sexual organ problem (amenorrhee femme,impotence sexuelle pour homme)
Hypothyroidism
quid of articular pain in hemochromatosis
Pseudo gout
cause of pseudogout
deposit of calcium pyrophosphate dihydrate in articulation
radiologic hallmark of pseudogout
chondrocalcinosis
cause of chondrocalcinosis(3)
Hypomagnesemie
Hyperparathyroidism
Hemochromatosis
confirmatory test for hemochromatosis(2)
HFE gene
liver biopsy
rx of hemochromatosis
phlebotomy
clue for TTP HUS(4)
Hemolytic anemia
low platelet
renal impairement
neurologic symptoms
rx of TTPHUS
Plasma exchange(plasmapheresis)
why plasma pherseis works
Because the disease in caused by antibody
what antibdy cause TTP-HUS
ADAMTS-13,antibody against von willebrand cleaving protease factor
explain low platelet in TTP-HUS(2)
accumulation ao von willebrand factor
and aggregation of platelets
Peripheral smear of TTP-HUS
fragmented cells
What’s the hallmark of fragmented cells
Microangiopathic hemolytic anemia
What’s trastuzumab
Monoclonal antibody
indication of trastuzumab
breast cancer with HER2 receptor
What to before beginning tratuzumab
echocardiographie
Breast cancer with progesterone and oestrogene receptor,rx?
chemotherapy
Thrombosis and low platelets days after initiating Heparin DX
thrombocytopenia induced by heparin
How to explain thrombosis in HIT
because the complexe Heparin -PF4-IGG activates platelets
sideroblastic anemia
inability to produce heme
What anemia can develop patients on anti TB drugs
sideroblastic anemia
why patient on anti TB can develop sideroblatic anemia
because of lack of B6
what ‘s the role of pyridoxine in erytropoiesis
protoporphyrin synthesis
cause of b6 deficiency(2)
alcohol
isoniazid
what’s salvage therapy
failure of standards rx
begin a second to eliminate the metastasis
adjuvant therapy
rx given in addition to the standard therapy
Neoadjuvant therapy
rx given before the standard therapy
cancer of esophagus associated with reflux disease
adenocarcinoma
ca of esophagus associated with cigarettes and alcohol
squamous cell carcinoma
workup of esophageal cancer(2)
baryum swallow
endoscopy and biopsy
work up for sqamous cell carcinoma of the skin
Punch biopsy
staging for esophageal cancer
Pet scan
most common cause of matastasis in brain
lung cancer
Multiple brain metastasis(2)
Lung
Malignant melanoma
solitary brain metastasis(3)
breast cancer
colon cancer
renal cancer
MEN 1 syndromes(3)
Pancreatic tumor
Pituatary adenoma
parathyroid hyperplasia
pancreatic tumor in MEN 1(4)
gastrinoma
vipoma
glucagonoma
insulinoma
quid zollinger ellisson syndrome
Multiple peptique ulcer rebelious to rx
management of sickle cell disease complicated by stroke
exchange transfusion
Long term treatment of sickle cell disease
hydroxyurea
action of hydroxyurea
Increase of HB F
Rx anorexia induced by cancer(2)
progesterone analog
Quid of progesterone analog(2)
Medroxy progesterone or
megestrol acetate
quid for amsterdam criteria
useful for lynch syndrome diagnosis
Criteria for Lynch syndrome(4)
at least 3 relatives with colon cancer ,one of them is first degree relative with the two others
two or more generation involved
at least one dx before 50
FAP has been excluded
quid of lynch
Hereditary non polyposis colorectal cancer
Quid of lynch 1
only colon is involved
quid of Lynch 2
colon plus extra colon involvement
The most common extra colon site for lynch 2
endometrial carcinoma
Ovarian cancer screening
BRCA 1
BRCA 2
Si BRCA genes positive what’s the next step in case of ovarian cancer workup(2)
CA-125
Pelvis ultrasound
Complication of EPO
iron deficiency anemia
why anemia in administration of EPO
rapid depletion of body’s iron store
Treatment of iron deficiency anemia in dyalisis patient
iron dextran
Population involved in G6PD deficiency
Afro american(black)
Peripheral smear of G6PD(2)
Heinz bodies
Bite cells
Physiopatho of Heinz bodies
oxydation of hB
Why Hb is easily oxydized in G6PD deficiency
because of lack of glutathione
role of G6PD
formation of NADPH
role of NADPH
cofactor in formation of gluthatione
what can cause hemolysis in G6PD deficiency(4)
fava beans
sulfa drugs
antimalaric drugs
nitrofurantoin
Next step iron deficinecy anemia in Men >40 ans
fecal occult blood
Next step iron deficiency anemia in menopause woman
fecal occult blood
what’s the most common cause of iron deficiency anemia in male or post menopausal women
chronic gastrointestinal blood loss
Best confirmatory test for HIT
serotonin release assay
Rx of HIT(2)
stop heparin
Direct thrombin inhibitor or
Fondaparinux
after how many day can begin HIT
after 5 days or more after the beginning of heparin treatment
Microcytic anemia non responsive to iron therapy
Thalassemie
epidemio of thalassemia
Europe descendant