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Mir > Hemato > Flashcards

Hemato Flashcards

1
Q

t (8;14) cmyc

A

burkitt cielo estrellado

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2
Q

t (11;14) bcl 1

A

L Manto (una persona debajo manta)

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3
Q

t (9;22)

A

LMC BCR/ABL cromosoma phidadlephia (en 5% ph negativo) buen pronostico
LLA M3: mal pronostico

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4
Q

t (14, 18)

A

Folicular

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5
Q

Pancitopenia sin esplenomegalia

A
  • Anemia aplásica

- SMD (menos Sme 5q: trombocitosis)

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6
Q

Aspirado seco

A
  • Aplasia medular (grasa)
  • Mielofibrosis
  • Tricoleucemia
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7
Q

Causa mas frecuente macrocitosis

A

Alcohol

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8
Q

No Adenopatias

A

Mieloma!

Tricoleucemia

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9
Q

Pancitopenia MAS esplenomegalia

A
  1. Mielofibrosis
  2. Tricoleucemia
  3. HPN
  4. LNH
  5. Leishmania
  6. Gaucher
  7. Cirrosis más HTP
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10
Q

Anemia macro

A
  • A Megalobástica ( neutrofilos hipersegmentados)
  • SMD (neutroflipos hoposegmentados: pseudopelger
  • Aplasia
  • Hipotiroidismo
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11
Q

Unica anemia hemolitica con hiperreticulocitosis

A

HPN

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12
Q

Trombosis venosas

A

HPN
PV
Trombocitemia Esencial

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13
Q

FAG (fosfatasa alcalina granulocitica) disminuida

A

HPN, LMC y SMD

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14
Q

FAG aumentada

A

PV

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15
Q

4 enfermedades prurito

A

PV
LHodking (EN)
Micosis fungoide
Mastocitosis sistémica

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16
Q

Sombras Gumbrecht

A

LLC

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17
Q

Ibrutinib

A

LLC si delecc17 y recaida Linfoma Manto

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18
Q

Brentuximab

A

Anti CD30 para LH Refractario

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19
Q

Decitabina

A

LAM > 65años no candidatos QT

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20
Q

5-Azacitidina

A

SMD con al estado general

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21
Q

Ttmo PTI

A

1º linea: Corticoides +/- gammaglobulina
2ºLinea: Esplenectomia o ANALOGOS DE LA TROMBOPOYETINA (MISMO nivel de evidencia!!)
Transfusiones NO contraindicadas pero poco efectivas

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22
Q

Tto PTT

A

Plasmaféresis y corticoides

CONTRAINDICADO TRAnSFUSIONES

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23
Q

Sintrom

A

aumenta TP (via corta. inhibe al 7) pero si esta muy pasado puede aumentar TTPA

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24
Q

Control HBPM excepciones

A

NO! solo antiXa en embarazadas obesos morbidos y IRC

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25
Q

Sintrom y cirugia vital <6h

A

Complejo protrombínico: concentrado de protrombina y vitK

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26
Q

Efectos adversos NACO

A

Hemorragia.

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27
Q

Unico NACO inhibidor

A

DA-BIgatran: iDA-rozumab

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28
Q

BCR-ABL t (9;22)

A

LMC: buen pronostico o LAL: MAL PRONOSTICO

29
Q

Eculizumab

A

HPN

30
Q

aumento CCMH

A

Esferocitosis hereditaria

31
Q

ID HUMORAL

A

LLc y MM

32
Q

ID celular

A

LH y tricoleucemia

33
Q

Hemofilia adquirida

A

aumento TP que no corrige con plasma- Mas frecuente ac anti8

34
Q

No trata asintomaticos

A

MM, LLC, Paget, Sarcoidosis, Hiperuricemia

35
Q

Dacriocito

A

mieloptisis

36
Q

Reaccion leucoeritroblastica

A

mieloptisis

37
Q

Tratamieto Aplasia medular

A

<45a ALOTPH

>45a ATG+Ciclosporina+Corticoides

38
Q

A ferropenica

A

1er dato: disminucion ferritina
3-6d Aumento reticulocitos
mantener FE 3-6m hasta restaurar FERRITINa no hasta quitar anemia!

39
Q

Causa mas frecuente A. megaloblastica

A

Deficit Ac folico (deposito 3-4m)
aumento HOMOCiSTEINA
Ac menilmandolico NORMAL

40
Q

Deficit B12

A 
Menos frecuente (depositos 3-6años) 
Sintomas neurologicos +/- anemia: compiten!! puede haber clinica SNC sin anemia
41
Q

Ttmo A. megaloblastica x deficit B12

A

B12 im + Folico!

42
Q

Anemia perniciosa

A

Preneoplasica AC mas sensible: anticelparietal

mas EspeciFIco antiFI

43
Q

A Hemolitica AC Calientes

A

Ig G (guarrillos), Extravasculares, LLC y LES

44
Q

A Hemolitica AC Frios

A

Ig M (modositos en casa) Intravasculares, VEB, mycoplasma, Waldestrom

45
Q

HPN

A

Hemolisis INTRAVASCULAR ADQUIRIDA.
Deficit CD55 y 59: activacion complemetnp
Trombopenia mas TROMBOSIS (Budd Chiari)
Eculizumab

46
Q

Bastones Auer

A

LAM

47
Q

Sme 5q

A

SMD mujeres con trombocitosis: ttmo LENALIDOMIDA

48
Q

Anemia macrocitica refractaria tto en mayor

A

SMD. NO DAR FE!

49
Q

Estadiaje BINET y RAI

A

LLC (CD 5+, 23+)

50
Q

Sme RITCHER

A

LLC que evoluciona a LDCG

51
Q

Esplenomegalia+ legionallea+ PAN

A

Tricoleucemia: Slinfoprol B. NO ADENOPATIAS

CD103+

52
Q

LNH mas frecuente occidente

A

LBCG (bcl 6)

53
Q

LNH bajo grado mas frecuente

A

L. Folicular (14,18) bcl2

54
Q

Ann Arbor

A

LH

55
Q

Cel Red Stenberg

A

CD 15+ 30+

56
Q

Sme Zieve

A

Hiperlipidemia Hemolisis y Hepatopatia

57
Q

pancitopenia, “orinas oscuras” y trombosis venosas

A

HPN

58
Q

CAusas anemia macro

A

hipotiroidismo, aplasia medular, smes mielodisplásico y a.megaloblastica

59
Q

Primera causa muerte MM

A

Infecciones: ID Humoral por Ac anomalos
2º insuficiencia renal por la excreción de cadenas ligeras (proteinuria de Bence-Jones) y la hipercalcemia
Peor pronostico: ausencia respuesta citostaticos

60
Q

anemia micro

A

ferropenica, intox plomo (sideroblastica), sideroblastica, talasemia ( nº hematies N o aumentado)

61
Q

leucemia aguda + CID

A

Leucemia M3 promielocitica: ATRA

62
Q

anciano pancitopenia + macrocitosis

A

SMD (menos 5q) NO dar Fe de ttmo!!!

63
Q

1º causa mortalidad LLC

A

infecciones: hipogammaglobulineamia

64
Q

LLC asint ttmo

A

Expectante

65
Q

neutropenia febril+fiebre+dolor fosa iliaca derecha

A

Tiflitis. Causa: PSEUDOMONAS A

66
Q

peor pronostico LLC

A

trombopenia (rai y binet)

67
Q

anemia + trombocitosis

A

ferrropenica. Trombocitosis reactiva x intento de compensacion

68
Q

ttmo MM <70A

A

QT altas dosis + AUTOTPH

69
Q

células T pleomórficas CD4 positivas+ lesiones liticas en linfomaL

A

LT adulto: virus HTLV1

Mir (14 decks)

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