Hema Flashcards

1
Q

Physiologic anemia of infancy usualy lasts for how many weeks?

A

8-12

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2
Q

Physiologic anemia of prematurity has hemoglobin levels of

A

7-9 g/dl

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3
Q

Does physiologic anemia of prematurity require treatment?

A

Yes EPO or transfusion

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4
Q

Most important sign of iron deficiency anemia

A

Pallor

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5
Q

Expected rise in hemoglobin per day after iron treatment

A

0.1-0.4 g/dl

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6
Q

Treatment for IDA

A

Elemental iron

3-6mg/kg/day

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7
Q

After treatment of IDA, Repeat CBC should be done after

A

4 weeks

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8
Q

Target cells
Heinz bodies
Decreased retic count
Normal RDW

A

Thalassemia

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9
Q

Definitive diagnosis of thalassemia can be done through

A

Hb electrophoresis

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10
Q

This infection should be watched out for in thalassemia because it eats up the free iron

A

Yersinia enterocolitica

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11
Q

Tachycardia and splenomegaly

Increased reticulocyte and MCHC normal platelet count

A

Spherocytosis

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12
Q

Defect in spectrin or ankyrin
Osmotic fragility test
Increased MCHC, retic count
Normal MCV

A

Spherocytosis

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13
Q

Vasoocclusive crisis
Autosomal recessive
Crew cut or hair on end appearance of skull in xray
Howell Jolly bodies

A

Sickle cell anemia

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14
Q

Treatment for sickle cell

A

Hydration and analgesia for acute crises

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15
Q

Most common hereditary bleeding disorder

A

vWD

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16
Q

Most common and most serious congenital coagulation factor deficiency?

A

Hemophilia A

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17
Q

Most common hereditary hypercoagulable disorder?

A

Factor V Leiden

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18
Q

Hallmark of hemophilia

A

Prolonged bleeding

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19
Q

Earliest joint hemorrhage in children

A

Ankles

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20
Q

Treatment for mild von willebrand disease type 1

A

Desmopressin

21
Q

Laboratory finding in hemophilia

A

Increased PTT

22
Q

Laboratory finding in vWD

A

Increased PTT and bleeding time

23
Q

Laboratory finding in ITP

A

Increased bleeding time

Decreased platelet

24
Q

Laboratory finding in vitamin K deficiency

A

Increased PT

25
Q

Laboratory finding in DIC

A

Decreased platelet count

Increased PT PTT bleeding time

26
Q

What type of leukemia in childhood will have the best response to chemotherapy?

A

ALL

27
Q

Site of relapse of ALL

A

bone marrow
CNS
Testes

28
Q

Site of spread of ALL

A

Liver
Spleen
Lymph nodes

29
Q
<2 years >10 years old
Male
WBC >100,000 on presentation 
CNS involvement 
Mediastinal mass

Poor prognostic factors of what disease

A

ALL

30
Q

Renal tumor of embryonal origin

A

Wilms tumor

31
Q

Painless abdominal enlargement with flank mass that DOES NOT cross the midline

A

Wilms

32
Q

Drug of choice for PCP prophylaxis in children with ALL undergoing chemotherapy is

A

Co-trimoxazole

33
Q

Embryonic tumor of neural crest origin

A

Neuroblastoma

34
Q

Most common site where neuroblasts migrate

A

Sympathetic ganglia and adrenals

35
Q

Differential diagnosis of small, round, blue cell tumors

WARMER PN

A
Wilms
Acute leukemia 
Rhabdomyosarcoma
Mesothelioma/medulloblastoma
Ewing sarcoma
Retinoblastoma
Primitive neuroectodermal tumor (PNET)
Neuroblastoma
36
Q

Associated with:
Neurofibromatosis
Beckwith- Weidemann syndrome
WAGR syndrome

A

Wilms tumor

37
Q
Associated with:
N-myc oncogene 
Neurofibromatosis
Hirschprung
Tuberous sclerosis
Pheochromocytoma
A

Neuroblastoma

38
Q
Horner syndrome
Abdominal mass that MAY cross the midline
Cord compression
Racoon eyes
Dancing eyes and feet
A

Neuroblastoma

39
Q

Diagnosis for neuroblastoma

A

Urine VMA and HVA
Abdominal CT
Bone marrow aspirate

40
Q
Long bones and skull
BM
Liver
LN
Skin 

Most common metastatic sites of

A

Neuroblastoma

41
Q

What are the B symptoms of

Lymphoma?

A

High grade fever
Weight loss
Night sweats

42
Q
Regional lymphadenopathy 
Chemotherapy
Bimodal age distribution 
EBV, CMV, HHV 6
Reed Sternberg cells
Contiguous LN spread
A

Hodgkin lymphoma

43
Q

Hodgkin lymphoma type that has the Best prognosis

A

Mixed cellularity lymphocyte predominant

44
Q
Systemic adenopathy
Radiation for CNS involvement
Chemotherapy 
60% of lymphomas in chidren and adolescent 
EBV- Burkitt
Non contiguous LN spread
A

Non-Hodgkin

45
Q

Results from failure or autoimmune destruction of myeloid stem cells

A

Aplastic anemia

46
Q

Most likely cause of aplastic anemia

A

Idiopathic

47
Q

Typical PBS finding in aplastic anemia

A

Hypocellularity and pancytopenia

48
Q

Aplastic anemia with microcephaly, microphthalmia, hearing loss and limb anomalies

A

Fanconi anemia